RAB35 (RAB35, member RAS oncogene family)

2003-12-01  

Identity

HGNC
LOCATION
12q24.23
LOCUSID
ALIAS
H-ray,RAB1C,RAY
FUSION GENES

Other Information

Locus ID:

NCBI: 11021
MIM: 604199
HGNC: 9774
Ensembl: ENSG00000111737

Variants:

dbSNP: 11021
ClinVar: 11021
TCGA: ENSG00000111737
COSMIC: RAB35

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111737ENST00000229340Q15286
ENSG00000111737ENST00000534951Q15286
ENSG00000111737ENST00000538903F5H157
ENSG00000111737ENST00000544304F5H7F8

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
RAB GEFs exchange GTP for GDP on RABsREACTOMER-HSA-8876198
TBC/RABGAPsREACTOMER-HSA-8854214
RAB geranylgeranylationREACTOMER-HSA-8873719

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
169501092006Rab35 regulates an endocytic recycling pathway essential for the terminal steps of cytokinesis.125
217060222011Rab35 GTPase and OCRL phosphatase remodel lipids and F-actin for successful cytokinesis.100
184507572008Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
197296552009Rab35 controls actin bundling by recruiting fascin as an effector protein.56
232647342013Interplay between Rab35 and Arf6 controls cargo recycling to coordinate cell adhesion and migration.52
222267462012An ARF6/Rab35 GTPase cascade for endocytic recycling and successful cytokinesis.43
220657582011Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate.39
263387972015Identification of an oncogenic RAB protein.36
233531822013Rab35 is required for Wnt5a/Dvl2-induced Rac1 activation and cell migration in MCF-7 breast cancer cells.29

Citation

Dessen P

RAB35 (RAB35, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41983/rab35-(rab35-member-ras-oncogene-family)