RAB38 (RAB38, member RAS oncogene family)

2003-05-01  

Identity

HGNC
RAB38
LOCATION
11q14.2
LOCUSID
23682
ALIAS
NY-MEL-1,rrGTPbp
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23682
MIM: 606281
HGNC: 9776
Ensembl: ENSG00000123892

Variants:

dbSNP: 23682
ClinVar: 23682
TCGA: ENSG00000123892
COSMIC: RAB38

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123892ENST00000243662P57729
ENSG00000123892ENST00000243662A0A024R191
ENSG00000123892ENST00000526372H0YDB7
ENSG00000123892ENST00000531138H0YEA4

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
RAB GEFs exchange GTP for GDP on RABsREACTOMER-HSA-8876198
RAB geranylgeranylationREACTOMER-HSA-8873719

References

Pubmed IDYearTitleCitations
230849912012BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor.102
225117742012BLOC-2, AP-3, and AP-1 proteins function in concert with Rab38 and Rab32 proteins to mediate protein trafficking to lysosome-related organelles.60
266317372016Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.40
253245512014Myosin vc interacts with Rab32 and Rab38 proteins and works in the biogenesis and secretion of melanosomes.26
201036242010Efficacious immune therapy in chronic myelogenous leukemia (CML) recognizes antigens that are expressed on CML progenitor cells.22
184774742008Varp interacts with Rab38 and functions as its potential effector.14
240261992013RAB38 confers a poor prognosis, associated with malignant progression and subtype preference in glioma.9
248753592014MiR-124 protects human hepatic L02 cells from H2O2-induced apoptosis by targeting Rab38 gene.6
128503052003Characterization of the human RAB38 and RAB7 genes: exclusion of new major pathological loci for Japanese OCA.3
305691142019High expression of RAB38 promotes malignant progression of pancreatic cancer.0

Citation

Dessen P

RAB38 (RAB38, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41986/rab38-(rab38-member-ras-oncogene-family)