RAB8A (RAB8A, member RAS oncogene family)

2003-02-01  

Identity

HGNC
LOCATION
19p13.11
LOCUSID
ALIAS
MEL,RAB8
FUSION GENES

Other Information

Locus ID:

NCBI: 4218
MIM: 165040
HGNC: 7007
Ensembl: ENSG00000167461

Variants:

dbSNP: 4218
ClinVar: 4218
TCGA: ENSG00000167461
COSMIC: RAB8A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167461ENST00000300935P61006
ENSG00000167461ENST00000300935A0A024R7I3
ENSG00000167461ENST00000586682P61006

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Tight junctionKEGGhsa04530
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
VxPx cargo-targeting to ciliumREACTOMER-HSA-5620916
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148
RAB GEFs exchange GTP for GDP on RABsREACTOMER-HSA-8876198
TBC/RABGAPsREACTOMER-HSA-8854214
RAB geranylgeranylationREACTOMER-HSA-8873719

References

Pubmed IDYearTitleCitations
203085582010Coordination of Rab8 and Rab11 in primary ciliogenesis.210
176464002007Functional dissection of Rab GTPases involved in primary cilium formation.172
187721922008CEP290 interacts with the centriolar satellite component PCM-1 and is required for Rab8 localization to the primary cilium.144
175977632007The Rab8 GTPase regulates apical protein localization in intestinal cells.134
173327562007MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway.99
175076472007Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3.87
215965662011Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers.68
264717302015Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1.62
224338572012A Rab8 guanine nucleotide exchange factor-effector interaction network regulates primary ciliogenesis.57
224453412012Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development.53

Citation

Dessen P

RAB8A (RAB8A, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42009/rab8a-(rab8a-member-ras-oncogene-family)