RAB9A (RAB9A, member RAS oncogene family)

2003-12-01  

Identity

HGNC
RAB9A
LOCATION
Xp22.2
LOCUSID
9367
ALIAS
RAB9
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9367
MIM: 300284
HGNC: 9792
Ensembl: ENSG00000123595

Variants:

dbSNP: 9367
ClinVar: 9367
TCGA: ENSG00000123595
COSMIC: RAB9A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123595ENST00000243325A0A1B0GUI0
ENSG00000123595ENST00000464506P51151
ENSG00000123595ENST00000464506A0A024RBV5
ENSG00000123595ENST00000618931P51151
ENSG00000123595ENST00000618931A0A024RBV5

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440
RAB GEFs exchange GTP for GDP on RABsREACTOMER-HSA-8876198
RAB geranylgeranylationREACTOMER-HSA-8873719

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
233455142013Identification of a role for the trans-Golgi network in human papillomavirus 16 pseudovirus infection.64
166447372006Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells.47
167698182006TIP47 is a key effector for Rab9 localization.44
200481592010Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9.35
224523362012The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infection.32
125765062003Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from Niemann-Pick C1 late endosomes.27
194009542009Vaccinia virus p37 interacts with host proteins associated with LE-derived transport vesicle biogenesis.27
218080682011RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins.26
186818382009Endosomal lipid accumulation in NPC1 leads to inhibition of PKC, hypophosphorylation of vimentin and Rab9 entrapment.22
244804192013TIP47 is associated with the hepatitis C virus and its interaction with Rab9 is required for release of viral particles.20

Citation

Dessen P

RAB9A (RAB9A, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/42011/rab9a-(rab9a-member-ras-oncogene-family)