RAC1 (Rac family small GTPase 1)

2003-02-01 Affiliation

Identity

HGNC

RAC1

LOCATION

7p22.1

LOCUSID

5879

ALIAS

MIG5,MRD48,Rac-1,TC-25,p21-Rac1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5879
MIM: 602048
HGNC: 9801
Ensembl: ENSG00000136238

Variants:

dbSNP: 5879
ClinVar: 5879
TCGA: ENSG00000136238
COSMIC: RAC1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000136238	ENST00000348035	P63000
ENSG00000136238	ENST00000348035	A4D2P1
ENSG00000136238	ENST00000356142	P63000
ENSG00000136238	ENST00000356142	A4D2P0

Expression (GTEx)

100

150

200

250

300

350

400

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
Wnt signaling pathway	KEGG	ko04310
Axon guidance	KEGG	ko04360
VEGF signaling pathway	KEGG	ko04370
Focal adhesion	KEGG	ko04510
Adherens junction	KEGG	ko04520
Tight junction	KEGG	ko04530
Toll-like receptor signaling pathway	KEGG	ko04620
Natural killer cell mediated cytotoxicity	KEGG	ko04650
B cell receptor signaling pathway	KEGG	ko04662
Fc epsilon RI signaling pathway	KEGG	ko04664
Leukocyte transendothelial migration	KEGG	ko04670
Regulation of actin cytoskeleton	KEGG	ko04810
Amyotrophic lateral sclerosis (ALS)	KEGG	ko05014
Epithelial cell signaling in Helicobacter pylori infection	KEGG	ko05120
Colorectal cancer	KEGG	ko05210
Renal cell carcinoma	KEGG	ko05211
Pancreatic cancer	KEGG	ko05212
MAPK signaling pathway	KEGG	hsa04010
Wnt signaling pathway	KEGG	hsa04310
Axon guidance	KEGG	hsa04360
VEGF signaling pathway	KEGG	hsa04370
Focal adhesion	KEGG	hsa04510
Adherens junction	KEGG	hsa04520
Tight junction	KEGG	hsa04530
Toll-like receptor signaling pathway	KEGG	hsa04620
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
B cell receptor signaling pathway	KEGG	hsa04662
Fc epsilon RI signaling pathway	KEGG	hsa04664
Leukocyte transendothelial migration	KEGG	hsa04670
Regulation of actin cytoskeleton	KEGG	hsa04810
Amyotrophic lateral sclerosis (ALS)	KEGG	hsa05014
Epithelial cell signaling in Helicobacter pylori infection	KEGG	hsa05120
Shigellosis	KEGG	hsa05131
Pathways in cancer	KEGG	hsa05200
Colorectal cancer	KEGG	hsa05210
Renal cell carcinoma	KEGG	hsa05211
Pancreatic cancer	KEGG	hsa05212
Chemokine signaling pathway	KEGG	ko04062
Chemokine signaling pathway	KEGG	hsa04062
Neurotrophin signaling pathway	KEGG	ko04722
Neurotrophin signaling pathway	KEGG	hsa04722
Fc gamma R-mediated phagocytosis	KEGG	ko04666
Fc gamma R-mediated phagocytosis	KEGG	hsa04666
Viral myocarditis	KEGG	hsa05416
Bacterial invasion of epithelial cells	KEGG	ko05100
Bacterial invasion of epithelial cells	KEGG	hsa05100
Phagosome	KEGG	ko04145
Phagosome	KEGG	hsa04145
Pancreatic secretion	KEGG	ko04972
Pancreatic secretion	KEGG	hsa04972
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
Salmonella infection	KEGG	ko05132
Salmonella infection	KEGG	hsa05132
Viral carcinogenesis	KEGG	hsa05203
Viral carcinogenesis	KEGG	ko05203
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
Non-alcoholic fatty liver disease (NAFLD)	KEGG	hsa04932
Non-alcoholic fatty liver disease (NAFLD)	KEGG	ko04932
Ras signaling pathway	KEGG	hsa04014
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Choline metabolism in cancer	KEGG	hsa05231
Choline metabolism in cancer	KEGG	ko05231
Sphingolipid signaling pathway	KEGG	hsa04071
Sphingolipid signaling pathway	KEGG	ko04071
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
HIV Infection	REACTOME	R-HSA-162906
Host Interactions of HIV factors	REACTOME	R-HSA-162909
The role of Nef in HIV-1 replication and disease pathogenesis	REACTOME	R-HSA-164952
Nef and signal transduction	REACTOME	R-HSA-164944
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Costimulation by the CD28 family	REACTOME	R-HSA-388841
CD28 co-stimulation	REACTOME	R-HSA-389356
CD28 dependent Vav1 pathway	REACTOME	R-HSA-389359
Innate Immune System	REACTOME	R-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosis	REACTOME	R-HSA-2029480
Regulation of actin dynamics for phagocytic cup formation	REACTOME	R-HSA-2029482
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
GPVI-mediated activation cascade	REACTOME	R-HSA-114604
Factors involved in megakaryocyte development and platelet production	REACTOME	R-HSA-983231
Signal Transduction	REACTOME	R-HSA-162582
Signalling by NGF	REACTOME	R-HSA-166520
p75 NTR receptor-mediated signalling	REACTOME	R-HSA-193704
Cell death signalling via NRAGE, NRIF and NADE	REACTOME	R-HSA-204998
NRAGE signals death through JNK	REACTOME	R-HSA-193648
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated vascular permeability	REACTOME	R-HSA-5218920
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK6/MAPK4 signaling	REACTOME	R-HSA-5687128
Signaling by Rho GTPases	REACTOME	R-HSA-194315
Rho GTPase cycle	REACTOME	R-HSA-194840
RHO GTPase Effectors	REACTOME	R-HSA-195258
RHO GTPases activate PAKs	REACTOME	R-HSA-5627123
RHO GTPases activate PKNs	REACTOME	R-HSA-5625740
RHO GTPases activate CIT	REACTOME	R-HSA-5625900
RHO GTPases activate KTN1	REACTOME	R-HSA-5625970
RHO GTPases activate IQGAPs	REACTOME	R-HSA-5626467
RHO GTPases Activate WASPs and WAVEs	REACTOME	R-HSA-5663213
RHO GTPases Activate Formins	REACTOME	R-HSA-5663220
RHO GTPases Activate NADPH Oxidases	REACTOME	R-HSA-5668599
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (12/13) signalling events	REACTOME	R-HSA-416482
Signaling by Wnt	REACTOME	R-HSA-195721
Beta-catenin independent WNT signaling	REACTOME	R-HSA-3858494
PCP/CE pathway	REACTOME	R-HSA-4086400
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
Translocation of GLUT4 to the plasma membrane	REACTOME	R-HSA-1445148
Cell-Cell communication	REACTOME	R-HSA-1500931
DSCAM interactions	REACTOME	R-HSA-376172
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
Semaphorin interactions	REACTOME	R-HSA-373755
Sema4D in semaphorin signaling	REACTOME	R-HSA-400685
Sema4D mediated inhibition of cell attachment and migration	REACTOME	R-HSA-416550
Sema4D induced cell migration and growth-cone collapse	REACTOME	R-HSA-416572
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	REACTOME	R-HSA-399955
Sema3A PAK dependent Axon repulsion	REACTOME	R-HSA-399954
Netrin-1 signaling	REACTOME	R-HSA-373752
DCC mediated attractive signaling	REACTOME	R-HSA-418885
Signaling by Robo receptor	REACTOME	R-HSA-376176
Inactivation of Cdc42 and Rac	REACTOME	R-HSA-428543
Activation of Rac	REACTOME	R-HSA-428540
L1CAM interactions	REACTOME	R-HSA-373760
Signal transduction by L1	REACTOME	R-HSA-445144
EPH-Ephrin signaling	REACTOME	R-HSA-2682334
EPHB-mediated forward signaling	REACTOME	R-HSA-3928662
Ephrin signaling	REACTOME	R-HSA-3928664
EPH-ephrin mediated repulsion of cells	REACTOME	R-HSA-3928665
AGE-RAGE signaling pathway in diabetic complications	KEGG	ko04933
AGE-RAGE signaling pathway in diabetic complications	KEGG	hsa04933
Signaling by PTK6	REACTOME	R-HSA-8848021
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	REACTOME	R-HSA-8849471
Neutrophil degranulation	REACTOME	R-HSA-6798695
Signaling by MET	REACTOME	R-HSA-6806834
MET promotes cell motility	REACTOME	R-HSA-8875878
MET activates RAP1 and RAC1	REACTOME	R-HSA-8875555
Fluid shear stress and atherosclerosis	KEGG	ko05418
Fluid shear stress and atherosclerosis	KEGG	hsa05418

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37540188	2024	LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress.	0
37642813	2024	Circular RNA circ_0058123 Targets the miR-939-5p/RAC1 Pathway to Promote the Development of Colorectal Cancer.	0
38141763	2024	The Snail signaling branch downstream of the TGF-β/Smad3 pathway mediates Rho activation and subsequent stress fiber formation.	3
38378644	2024	HMGB1 promotes mitochondrial transfer between hepatocellular carcinoma cells through RHOT1 and RAC1 under hypoxia.	0
38424547	2024	Tight junction protein cingulin variant is associated with cancer susceptibility by overexpressed IQGAP1 and Rac1-dependent epithelial-mesenchymal transition.	1
38508474	2024	PlexinA1 promotes gastric cancer migration through preventing MICAL1 protein ubiquitin/proteasome-mediated degradation in a Rac1-dependent manner.	0
37540188	2024	LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress.	0
37642813	2024	Circular RNA circ_0058123 Targets the miR-939-5p/RAC1 Pathway to Promote the Development of Colorectal Cancer.	0
38141763	2024	The Snail signaling branch downstream of the TGF-β/Smad3 pathway mediates Rho activation and subsequent stress fiber formation.	3
38378644	2024	HMGB1 promotes mitochondrial transfer between hepatocellular carcinoma cells through RHOT1 and RAC1 under hypoxia.	0
38424547	2024	Tight junction protein cingulin variant is associated with cancer susceptibility by overexpressed IQGAP1 and Rac1-dependent epithelial-mesenchymal transition.	1
38508474	2024	PlexinA1 promotes gastric cancer migration through preventing MICAL1 protein ubiquitin/proteasome-mediated degradation in a Rac1-dependent manner.	0
35241625	2023	Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation.	9
36054930	2023	A distinct pattern of growth and RAC1 signaling in melanoma brain metastasis cells.	3
36446524	2023	Loss of cell-cell adhesion triggers cell migration through Rac1-dependent ROS generation.	3

Citation

Dessen P

RAC1 (Rac family small GTPase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42020