RAD23A (RAD23 homolog A, nucleotide excision repair protein)

2003-02-01  

Identity

HGNC
RAD23A
LOCATION
19p13.13
LOCUSID
5886
ALIAS
HHR23A,HR23A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5886
MIM: 600061
HGNC: 9812
Ensembl: ENSG00000179262

Variants:

dbSNP: 5886
ClinVar: 5886
TCGA: ENSG00000179262
COSMIC: RAD23A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179262ENST00000316856P54725
ENSG00000179262ENST00000586375K7ELU6
ENSG00000179262ENST00000586534P54725
ENSG00000179262ENST00000586534A0A024R7G8
ENSG00000179262ENST00000590881K7EQ16
ENSG00000179262ENST00000591499K7ELW1
ENSG00000179262ENST00000592268P54725
ENSG00000179262ENST00000593114K7ENJ0
ENSG00000179262ENST00000651137A0A494C0B4

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Nucleotide excision repairKEGGko03420
Nucleotide excision repairKEGGhsa03420
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
DNA Damage Recognition in GG-NERREACTOMER-HSA-5696394
Formation of Incision Complex in GG-NERREACTOMER-HSA-5696395
DeubiquitinationREACTOMER-HSA-5688426
Josephin domain DUBsREACTOMER-HSA-5689877

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
343566322021Kinetic Constraints in the Specific Interaction between Phosphorylated Ubiquitin and Proteasomal Shuttle Factors.2
348242042021Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A.6
343566322021Kinetic Constraints in the Specific Interaction between Phosphorylated Ubiquitin and Proteasomal Shuttle Factors.2
348242042021Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A.6
322094752020Histone H4K20 Demethylation by Two hHR23 Proteins.16
322094752020Histone H4K20 Demethylation by Two hHR23 Proteins.16
314875042019HR23A-knockdown lung cancer cells exhibit epithelial-to-mesenchymal transition and gain stemness properties through increased Twist1 stability.1
314875042019HR23A-knockdown lung cancer cells exhibit epithelial-to-mesenchymal transition and gain stemness properties through increased Twist1 stability.1
277714512017Two mammalian homologs of yeast Rad23, HR23A and HR23B, as multifunctional proteins.10
277714512017Two mammalian homologs of yeast Rad23, HR23A and HR23B, as multifunctional proteins.10
276130962016Human Rad23A plays a regulatory role in autophagy.2
276130962016Human Rad23A plays a regulatory role in autophagy.2
262966562015hHR23A is required to control the basal turnover of Chk1.2
262966562015hHR23A is required to control the basal turnover of Chk1.2
243189822014Binding of HIV-1 Vpr protein to the human homolog of the yeast DNA repair protein RAD23 (hHR23A) requires its xeroderma pigmentosum complementation group C binding (XPCB) domain as well as the ubiquitin-associated 2 (UBA2) domain.6

Citation

Dessen P

RAD23A (RAD23 homolog A, nucleotide excision repair protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42027/rad23a-(rad23-homolog-a-nucleotide-excision-repair-protein)