RAPGEF2 (Rap guanine nucleotide exchange factor 2)

2003-11-01  

Identity

HGNC
RAPGEF2
LOCATION
4q32.1
LOCUSID
9693
ALIAS
CNrasGEF,NRAPGEP,PDZ-GEF1,PDZGEF1,RA-GEF,RA-GEF-1,RAGEF,Rap-GEP,nRap
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9693
MIM: 609530
HGNC: 16854
Ensembl: ENSG00000109756

Variants:

dbSNP: 9693
ClinVar: 9693
TCGA: ENSG00000109756
COSMIC: RAPGEF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109756ENST00000264431Q9Y4G8
ENSG00000109756ENST00000502485H0Y8T6
ENSG00000109756ENST00000505026H0YAJ8
ENSG00000109756ENST00000505478H0Y905
ENSG00000109756ENST00000510253H0Y8H7
ENSG00000109756ENST00000510510D6RAK0
ENSG00000109756ENST00000511336D6REY8
ENSG00000109756ENST00000512056H0Y8N8
ENSG00000109756ENST00000514565D6RC78
ENSG00000109756ENST00000644474A0A2R8YGD3
ENSG00000109756ENST00000644902A0A2R8Y661

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Tight junctionKEGGko04530
MAPK signaling pathwayKEGGhsa04010
Tight junctionKEGGhsa04530
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
RAF/MAP kinase cascadeREACTOMER-HSA-5673001
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
FCERI mediated MAPK activationREACTOMER-HSA-2871796
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-2 signalingREACTOMER-HSA-451927
Interleukin receptor SHC signalingREACTOMER-HSA-912526
Interleukin-3, 5 and GM-CSF signalingREACTOMER-HSA-512988
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
GRB2 events in EGFR signalingREACTOMER-HSA-179812
SHC1 events in EGFR signalingREACTOMER-HSA-180336
Signaling by Insulin receptorREACTOMER-HSA-74752
Insulin receptor signalling cascadeREACTOMER-HSA-74751
IRS-mediated signallingREACTOMER-HSA-112399
SOS-mediated signallingREACTOMER-HSA-112412
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Signalling to ERKsREACTOMER-HSA-187687
Signalling to RASREACTOMER-HSA-167044
Signalling to p38 via RIT and RINREACTOMER-HSA-187706
Prolonged ERK activation eventsREACTOMER-HSA-169893
Frs2-mediated activationREACTOMER-HSA-170968
ARMS-mediated activationREACTOMER-HSA-170984
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
VEGFR2 mediated cell proliferationREACTOMER-HSA-5218921
Signaling by SCF-KITREACTOMER-HSA-1433557
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK1/MAPK3 signalingREACTOMER-HSA-5684996
Signaling by GPCRREACTOMER-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)REACTOMER-HSA-2404192
IGF1R signaling cascadeREACTOMER-HSA-2428924
IRS-related events triggered by IGF1RREACTOMER-HSA-2428928
Signaling by LeptinREACTOMER-HSA-2586552
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
NCAM signaling for neurite out-growthREACTOMER-HSA-375165
RET signalingREACTOMER-HSA-8853659

References

Pubmed IDYearTitleCitations
333454002021RAPGEF2 mediates oligomeric Aβ-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer's disease.10
333454002021RAPGEF2 mediates oligomeric Aβ-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer's disease.10
311713762019Disruption of MAGI2-RapGEF2-Rap1 signaling contributes to podocyte dysfunction in congenital nephrotic syndrome caused by mutations in MAGI2.9
311713762019Disruption of MAGI2-RapGEF2-Rap1 signaling contributes to podocyte dysfunction in congenital nephrotic syndrome caused by mutations in MAGI2.9
253322352015Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.38
253322352015Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.38
248588082014The PDZ domain of the guanine nucleotide exchange factor PDZGEF directs binding to phosphatidic acid during brush border formation.7
251891712014Cdk5-mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex.32
248588082014The PDZ domain of the guanine nucleotide exchange factor PDZGEF directs binding to phosphatidic acid during brush border formation.7
251891712014Cdk5-mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex.32
238004692013Rapgef2 connects GPCR-mediated cAMP signals to ERK activation in neuronal and endocrine cells.37
238851232013JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.73
242909812013Control of epithelial cell migration and invasion by the IKKβ- and CK1α-mediated degradation of RAPGEF2.20
243400592013NEDD4-1 regulates migration and invasion of glioma cells through CNrasGEF ubiquitination in vitro.21
238004692013Rapgef2 connects GPCR-mediated cAMP signals to ERK activation in neuronal and endocrine cells.37

Citation

Dessen P

RAPGEF2 (Rap guanine nucleotide exchange factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42046/rapgef2-(rap-guanine-nucleotide-exchange-factor-2)