RASSF4 (Ras association domain family member 4)

2003-10-01 Affiliation

Identity

HGNC

RASSF4

LOCATION

10q11.21

LOCUSID

83937

ALIAS

AD037

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 83937
MIM: 610559
HGNC: 20793
Ensembl: ENSG00000107551

Variants:

dbSNP: 83937
ClinVar: 83937
TCGA: ENSG00000107551
COSMIC: RASSF4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000107551	ENST00000340258	Q9H2L5
ENSG00000107551	ENST00000427758	Q5T739
ENSG00000107551	ENST00000428466	Q5T737
ENSG00000107551	ENST00000483709	R4GNA4
ENSG00000107551	ENST00000484477	V9GYK1

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Hippo signaling pathway -multiple species	KEGG	ko04392
Hippo signaling pathway -multiple species	KEGG	hsa04392

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
34121238	2021	Wnt/β-catenin signaling pathway participates in the effect of miR-626 on oral squamous cell carcinoma by targeting RASSF4.	5
34121238	2021	Wnt/β-catenin signaling pathway participates in the effect of miR-626 on oral squamous cell carcinoma by targeting RASSF4.	5
31508857	2020	RASSF4 is required for skeletal muscle differentiation.	1
31508857	2020	RASSF4 is required for skeletal muscle differentiation.	1
29259009	2018	Loss of RASSF4 Expression in Multiple Myeloma Promotes RAS-Driven Malignant Progression.	21
29259009	2018	Loss of RASSF4 Expression in Multiple Myeloma Promotes RAS-Driven Malignant Progression.	21
28081736	2017	RASSF4 Overexpression Inhibits the Proliferation, Invasion, EMT, and Wnt Signaling Pathway in Osteosarcoma Cells.	14
28600435	2017	RASSF4 controls SOCE and ER-PM junctions through regulation of PI(4,5)P(2).	36
28081736	2017	RASSF4 Overexpression Inhibits the Proliferation, Invasion, EMT, and Wnt Signaling Pathway in Osteosarcoma Cells.	14
28600435	2017	RASSF4 controls SOCE and ER-PM junctions through regulation of PI(4,5)P(2).	36
26526576	2016	RASSF4 is downregulated in nonsmall cell lung cancer and inhibits cancer cell proliferation and invasion.	15
26526576	2016	RASSF4 is downregulated in nonsmall cell lung cancer and inhibits cancer cell proliferation and invasion.	15
25701784	2015	RASSF4 promotes EV71 replication to accelerate the inhibition of the phosphorylation of AKT.	6
25701784	2015	RASSF4 promotes EV71 replication to accelerate the inhibition of the phosphorylation of AKT.	6
23954638	2013	Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signal.	19

Citation

Dessen P

RASSF4 (Ras association domain family member 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/42058/rassf4-(ras-association-domain-family-member-4)