RB1CC1 (RB1 inducible coiled-coil 1)

2003-02-01  

Identity

HGNC
LOCATION
8q11.23
LOCUSID
ALIAS
ATG17,CC1,FIP200,PPP1R131
FUSION GENES

Other Information

Locus ID:

NCBI: 9821
MIM: 606837
HGNC: 15574
Ensembl: ENSG00000023287

Variants:

dbSNP: 9821
ClinVar: 9821
TCGA: ENSG00000023287
COSMIC: RB1CC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000023287ENST00000025008Q8TDY2
ENSG00000023287ENST00000435644Q8TDY2
ENSG00000023287ENST00000517963E5RH44
ENSG00000023287ENST00000518211E5RJC1
ENSG00000023287ENST00000518468E5RHX0
ENSG00000023287ENST00000518710E5RH63
ENSG00000023287ENST00000519912H0YC30
ENSG00000023287ENST00000523594H0YC28

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Longevity regulating pathwayKEGGhsa04211

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
388213502024FIP200 Phosphorylation Regulates Late Steps in Mitophagy.0
388213502024FIP200 Phosphorylation Regulates Late Steps in Mitophagy.0
363943582023Regulation of RB1CC1/FIP200 stability and autophagy function by CREBBP-mediated acetylation in an intrinsically disordered region.5
368922222023A novel role of ATG9A and RB1CC1/FIP200 in mediating cell-death checkpoints to repress TNF cytotoxicity.0
371378862023Loss of function of FIP200 in human pluripotent stem cell-derived neurons leads to axonal pathology and hyperactivity.1
376155362023METTL14 inhibits malignant progression of oral squamous cell carcinoma by targeting the autophagy-related gene RB1CC1 in an m6A-IGF2BP2-dependent manner.2
363943582023Regulation of RB1CC1/FIP200 stability and autophagy function by CREBBP-mediated acetylation in an intrinsically disordered region.5
368922222023A novel role of ATG9A and RB1CC1/FIP200 in mediating cell-death checkpoints to repress TNF cytotoxicity.0
371378862023Loss of function of FIP200 in human pluripotent stem cell-derived neurons leads to axonal pathology and hyperactivity.1
376155362023METTL14 inhibits malignant progression of oral squamous cell carcinoma by targeting the autophagy-related gene RB1CC1 in an m6A-IGF2BP2-dependent manner.2
350683262022Circ-CUL2/microRNA-888-5p/RB1CC1 axis participates in cisplatin resistance in NSCLC via repressing cell advancement.5
350683262022Circ-CUL2/microRNA-888-5p/RB1CC1 axis participates in cisplatin resistance in NSCLC via repressing cell advancement.5
336821332021The ERK1/2-ATG13-FIP200 signaling cascade is required for autophagy induction to protect renal cells from hypoglycemia-induced cell death.2
337947262021ATG14 and RB1CC1 play essential roles in maintaining muscle homeostasis.3
338378502021RB1CC1 functions as a tumor-suppressing gene in renal cell carcinoma via suppression of PYK2 activity and disruption of TAZ-mediated PDL1 transcription activation.7

Citation

Dessen P

RB1CC1 (RB1 inducible coiled-coil 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42060/rb1cc1-(rb1-inducible-coiled-coil-1)