RBBP4 (RB binding protein 4, chromatin remodeling factor)

2003-02-01  

Identity

HGNC
LOCATION
1p35.1
LOCUSID
ALIAS
NURF55,RBAP48,lin-53
FUSION GENES

Other Information

Locus ID:

NCBI: 5928
MIM: 602923
HGNC: 9887
Ensembl: ENSG00000162521

Variants:

dbSNP: 5928
ClinVar: 5928
TCGA: ENSG00000162521
COSMIC: RBBP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162521ENST00000373485Q09028
ENSG00000162521ENST00000373493Q09028
ENSG00000162521ENST00000414241Q09028
ENSG00000162521ENST00000445722C9JPP3
ENSG00000162521ENST00000458695Q09028
ENSG00000162521ENST00000460669H0YCT5
ENSG00000162521ENST00000463378H0YDK2
ENSG00000162521ENST00000475321H0YF10
ENSG00000162521ENST00000477563E9PNS6
ENSG00000162521ENST00000482190H0YEU5
ENSG00000162521ENST00000490500E9PND5
ENSG00000162521ENST00000492348E9PIC4
ENSG00000162521ENST00000526193E9PIC4
ENSG00000162521ENST00000527118E9PNS2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase I TranscriptionREACTOMER-HSA-73864
RNA Polymerase I Promoter ClearanceREACTOMER-HSA-73854
RNA Polymerase I Transcription InitiationREACTOMER-HSA-73762
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
PRC2 methylates histones and DNAREACTOMER-HSA-212300
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G0 and Early G1REACTOMER-HSA-1538133
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Polo-like kinase mediated eventsREACTOMER-HSA-156711
Chromosome MaintenanceREACTOMER-HSA-73886
Nucleosome assemblyREACTOMER-HSA-774815
Deposition of new CENPA-containing nucleosomes at the centromereREACTOMER-HSA-606279
Developmental BiologyREACTOMER-HSA-1266738
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDACs deacetylate histonesREACTOMER-HSA-3214815
PKMTs methylate histone lysinesREACTOMER-HSA-3214841
Positive epigenetic regulation of rRNA expressionREACTOMER-HSA-5250913
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through AcetylationREACTOMER-HSA-6804758
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expressionREACTOMER-HSA-427389

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
239863992013Molecular mechanism for age-related memory loss: the histone-binding protein RbAp48.47
210477982011Insights into association of the NuRD complex with FOG-1 from the crystal structure of an RbAp48·FOG-1 complex.45
249206722014Insight into the architecture of the NuRD complex: structure of the RbAp48-MTA1 subcomplex.30
231784552013Structural plasticity of histones H3-H4 facilitates their allosteric exchange between RbAp48 and ASF1.27
270988402016The structure of the core NuRD repression complex provides insights into its interaction with chromatin.24
190153072008Expression of the retinoblastoma protein RbAp48 in exocrine glands leads to Sjögren's syndrome-like autoimmune exocrinopathy.23
149669072004Genes encoding Pir51, Beclin 1, RbAp48 and aldolase b are up or down-regulated in human primary hepatocellular carcinoma.22
269720012016Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins.16
176165262007RbAp48 is a critical mediator controlling the transforming activity of human papillomavirus type 16 in cervical cancer.15

Citation

Dessen P

RBBP4 (RB binding protein 4, chromatin remodeling factor)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42062/rbbp4-(rb-binding-protein-4-chromatin-remodeling-factor)