RBBP4 (RB binding protein 4, chromatin remodeling factor)

2003-02-01 Affiliation

Identity

HGNC

RBBP4

LOCATION

1p35.1

LOCUSID

5928

ALIAS

NURF55,RBAP48,lin-53

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5928
MIM: 602923
HGNC: 9887
Ensembl: ENSG00000162521

Variants:

dbSNP: 5928
ClinVar: 5928
TCGA: ENSG00000162521
COSMIC: RBBP4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000162521	ENST00000373485	Q09028
ENSG00000162521	ENST00000373493	Q09028
ENSG00000162521	ENST00000414241	Q09028
ENSG00000162521	ENST00000445722	C9JPP3
ENSG00000162521	ENST00000458695	Q09028
ENSG00000162521	ENST00000460669	H0YCT5
ENSG00000162521	ENST00000463378	H0YDK2
ENSG00000162521	ENST00000475321	H0YF10
ENSG00000162521	ENST00000477563	E9PNS6
ENSG00000162521	ENST00000482190	H0YEU5
ENSG00000162521	ENST00000490500	E9PND5
ENSG00000162521	ENST00000492348	E9PIC4
ENSG00000162521	ENST00000526193	E9PIC4
ENSG00000162521	ENST00000527118	E9PNS2

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	REACTOME	R-HSA-504046
RNA Polymerase I Transcription	REACTOME	R-HSA-73864
RNA Polymerase I Promoter Clearance	REACTOME	R-HSA-73854
RNA Polymerase I Transcription Initiation	REACTOME	R-HSA-73762
Epigenetic regulation of gene expression	REACTOME	R-HSA-212165
PRC2 methylates histones and DNA	REACTOME	R-HSA-212300
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
Mitotic G1-G1/S phases	REACTOME	R-HSA-453279
G0 and Early G1	REACTOME	R-HSA-1538133
Mitotic G2-G2/M phases	REACTOME	R-HSA-453274
G2/M Transition	REACTOME	R-HSA-69275
Polo-like kinase mediated events	REACTOME	R-HSA-156711
Chromosome Maintenance	REACTOME	R-HSA-73886
Nucleosome assembly	REACTOME	R-HSA-774815
Deposition of new CENPA-containing nucleosomes at the centromere	REACTOME	R-HSA-606279
Developmental Biology	REACTOME	R-HSA-1266738
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular Senescence	REACTOME	R-HSA-2559583
Oxidative Stress Induced Senescence	REACTOME	R-HSA-2559580
Chromatin organization	REACTOME	R-HSA-4839726
Chromatin modifying enzymes	REACTOME	R-HSA-3247509
HDACs deacetylate histones	REACTOME	R-HSA-3214815
PKMTs methylate histone lysines	REACTOME	R-HSA-3214841
Positive epigenetic regulation of rRNA expression	REACTOME	R-HSA-5250913
Activation of HOX genes during differentiation	REACTOME	R-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesis	REACTOME	R-HSA-5617472
Regulation of TP53 Activity	REACTOME	R-HSA-5633007
Regulation of TP53 Activity through Acetylation	REACTOME	R-HSA-6804758
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	REACTOME	R-HSA-427389

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38577935	2024	Interpreting the molecular mechanisms of RBBP4/7 and their roles in human diseases (Review).	0
38577935	2024	Interpreting the molecular mechanisms of RBBP4/7 and their roles in human diseases (Review).	0
36691322	2023	Circ_0110498 facilitates the cisplatin resistance of non-small cell lung cancer by mediating the miR-1287-5p/RBBP4 axis.	5
36736531	2023	RBBP4 regulates the expression of the Mre11-Rad50-NBS1 (MRN) complex and promotes DNA double-strand break repair to mediate glioblastoma chemoradiotherapy resistance.	6
36881338	2023	CircAGO2 promotes colorectal cancer progression by inhibiting heat shock protein family B (small) member 8 via miR-1-3p/retinoblastoma binding protein 4 axis.	2
36691322	2023	Circ_0110498 facilitates the cisplatin resistance of non-small cell lung cancer by mediating the miR-1287-5p/RBBP4 axis.	5
36736531	2023	RBBP4 regulates the expression of the Mre11-Rad50-NBS1 (MRN) complex and promotes DNA double-strand break repair to mediate glioblastoma chemoradiotherapy resistance.	6
36881338	2023	CircAGO2 promotes colorectal cancer progression by inhibiting heat shock protein family B (small) member 8 via miR-1-3p/retinoblastoma binding protein 4 axis.	2
34709113	2022	Overlapping functions of RBBP4 and RBBP7 in regulating cell proliferation and histone H3.3 deposition during mouse preimplantation development.	10
35231103	2022	RBBP4-p300 axis modulates expression of genes essential for cell survival and is a potential target for therapy in glioblastoma.	6
35622231	2022	RBBP4 plays a vital role in the malignant progression of triple-negative breast cancer by regulating epithelial-mesenchymal transition.	3
34709113	2022	Overlapping functions of RBBP4 and RBBP7 in regulating cell proliferation and histone H3.3 deposition during mouse preimplantation development.	10
35231103	2022	RBBP4-p300 axis modulates expression of genes essential for cell survival and is a potential target for therapy in glioblastoma.	6
35622231	2022	RBBP4 plays a vital role in the malignant progression of triple-negative breast cancer by regulating epithelial-mesenchymal transition.	3
32994691	2020	RBBP4 promotes colon cancer malignant progression via regulating Wnt/β-catenin pathway.	12

Citation

Dessen P

RBBP4 (RB binding protein 4, chromatin remodeling factor)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42062/rbbp4-(rb-binding-protein-4-chromatin-remodeling-factor)