RBBP6 (RB binding protein 6, ubiquitin ligase)

2003-08-01  

Identity

HGNC
RBBP6
LOCATION
16p12.1
LOCUSID
5930
ALIAS
MY038,P2P-R,PACT,RBQ-1,SNAMA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5930
MIM: 600938
HGNC: 9889
Ensembl: ENSG00000122257

Variants:

dbSNP: 5930
ClinVar: 5930
TCGA: ENSG00000122257
COSMIC: RBBP6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122257ENST00000319715Q7Z6E9
ENSG00000122257ENST00000348022Q7Z6E9
ENSG00000122257ENST00000381039Q7Z6E9
ENSG00000122257ENST00000452655Q7Z6E9
ENSG00000122257ENST00000562683A0A087WY32
ENSG00000122257ENST00000564314H3BSK8
ENSG00000122257ENST00000567686H3BUN0
ENSG00000122257ENST00000568015I3L3Y2
ENSG00000122257ENST00000646282A0A2R8Y880

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
373226272023Abnormal expression of long non-coding RNA FGD5-AS1 affects the development of ovarian cancer through regulating miR-107/RBBP6 axis.0
373226272023Abnormal expression of long non-coding RNA FGD5-AS1 affects the development of ovarian cancer through regulating miR-107/RBBP6 axis.0
351775362022RBBP6 activates the pre-mRNA 3' end processing machinery in humans.23
351775362022RBBP6 activates the pre-mRNA 3' end processing machinery in humans.23
336830132021The lncRNA SLCO4A1-AS1/miR-876-3p/RBBP6 axis regulates cell proliferation and apoptosis in acute lymphocytic leukemia via the JNK signaling pathway.4
336830132021The lncRNA SLCO4A1-AS1/miR-876-3p/RBBP6 axis regulates cell proliferation and apoptosis in acute lymphocytic leukemia via the JNK signaling pathway.4
326628982020Analysis of the expression and association of retinoblastoma binding protein 6 with the JNK signaling pathway in prostate cancers.1
331551922020RBBP6 aggravates the progression of ovarian cancer by targeting PIK3R6.2
326628982020Analysis of the expression and association of retinoblastoma binding protein 6 with the JNK signaling pathway in prostate cancers.1
331551922020RBBP6 aggravates the progression of ovarian cancer by targeting PIK3R6.2
308275072019PACT cessation overcomes ovarian cancer cell chemoresistance to cisplatin by enhancing p53-mediated apoptotic pathway.7
316858012019RBBP6, a RING finger-domain E3 ubiquitin ligase, induces epithelial-mesenchymal transition and promotes metastasis of colorectal cancer.18
308275072019PACT cessation overcomes ovarian cancer cell chemoresistance to cisplatin by enhancing p53-mediated apoptotic pathway.7
316858012019RBBP6, a RING finger-domain E3 ubiquitin ligase, induces epithelial-mesenchymal transition and promotes metastasis of colorectal cancer.18
293694812018RBBP6 increases radioresistance and serves as a therapeutic target for preoperative radiotherapy in colorectal cancer.13

Citation

Dessen P

RBBP6 (RB binding protein 6, ubiquitin ligase)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42064/rbbp6-(rb-binding-protein-6-ubiquitin-ligase)