RDH11 (retinol dehydrogenase 11)

2003-02-01  

Identity

HGNC
RDH11
LOCATION
14q24.1
LOCUSID
51109
ALIAS
ARSDR1,CGI82,HCBP12,MDT1,PSDR1,RALR1,RDJCSS,SCALD,SDR7C1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51109
MIM: 607849
HGNC: 17964
Ensembl: ENSG00000072042

Variants:

dbSNP: 51109
ClinVar: 51109
TCGA: ENSG00000072042
COSMIC: RDH11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000072042ENST00000381346Q8TC12
ENSG00000072042ENST00000381346A0A0S2Z583
ENSG00000072042ENST00000428130Q8TC12
ENSG00000072042ENST00000553384Q8TC12
ENSG00000072042ENST00000554035H0YJ46
ENSG00000072042ENST00000554731G3V3K0
ENSG00000072042ENST00000557273G3V2G6
ENSG00000072042ENST00000557331G3V510
ENSG00000072042ENST00000557726G3V234

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Retinol metabolismKEGGko00830
Retinol metabolismKEGGhsa00830
Metabolic pathwaysKEGGhsa01100
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
Retinoid metabolism and transportREACTOMER-HSA-975634
The canonical retinoid cycle in rods (twilight vision)REACTOMER-HSA-2453902
Signaling by Retinoic AcidREACTOMER-HSA-5362517
RA biosynthesis pathwayREACTOMER-HSA-5365859
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of fat-soluble vitaminsREACTOMER-HSA-6806667

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
255427822015Structure of the N-terminal segment of human retinol dehydrogenase 11 and its preferential lipid binding using model membranes.4
258291922015Ribosomal protein L11- and retinol dehydrogenase 11-induced erythroid proliferation without erythropoietin in UT-7/Epo erythroleukemic cells.2
255427822015Structure of the N-terminal segment of human retinol dehydrogenase 11 and its preferential lipid binding using model membranes.4
258291922015Ribosomal protein L11- and retinol dehydrogenase 11-induced erythroid proliferation without erythropoietin in UT-7/Epo erythroleukemic cells.2
249163802014New syndrome with retinitis pigmentosa is caused by nonsense mutations in retinol dehydrogenase RDH11.17
249163802014New syndrome with retinitis pigmentosa is caused by nonsense mutations in retinol dehydrogenase RDH11.17
172496162006Photoreceptor retinol dehydrogenases. An attempt to characterize the function of Rdh11.1
172496162006Photoreceptor retinol dehydrogenases. An attempt to characterize the function of Rdh11.1
125324532003Interaction between hepatitis C virus core protein and translin protein--a possible molecular mechanism for hepatocellular carcinoma and lymphoma caused by hepatitis C virus.4
146747582003Properties of short-chain dehydrogenase/reductase RalR1: characterization of purified enzyme, its orientation in the microsomal membrane, and distribution in human tissues and cell lines.31
125324532003Interaction between hepatitis C virus core protein and translin protein--a possible molecular mechanism for hepatocellular carcinoma and lymphoma caused by hepatitis C virus.4
146747582003Properties of short-chain dehydrogenase/reductase RalR1: characterization of purified enzyme, its orientation in the microsomal membrane, and distribution in human tissues and cell lines.31
120369562002Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1).23
120369562002Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1).23

Citation

Dessen P

RDH11 (retinol dehydrogenase 11)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42080/rdh11-(retinol-dehydrogenase-11)