REV3L (REV3 like, DNA directed polymerase zeta catalytic subunit)

2003-02-01  

Identity

HGNC
REV3L
LOCATION
6q21
LOCUSID
5980
ALIAS
POLZ,REV3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5980
MIM: 602776
HGNC: 9968
Ensembl: ENSG00000009413

Variants:

dbSNP: 5980
ClinVar: 5980
TCGA: ENSG00000009413
COSMIC: REV3L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000009413ENST00000358835O60673
ENSG00000009413ENST00000368802O60673
ENSG00000009413ENST00000413831H0Y5T4
ENSG00000009413ENST00000422377F2Z3A1
ENSG00000009413ENST00000434009F2Z3A1
ENSG00000009413ENST00000435970O60673
ENSG00000009413ENST00000619481A0A087WZU4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolic pathwaysKEGGhsa01100
Fanconi anemia pathwayKEGGko03460
Fanconi anemia pathwayKEGGhsa03460
DNA polymerase zeta complexKEGGhsa_M00293
DNA polymerase zeta complexKEGGM00293
DNA RepairREACTOMER-HSA-73894
DNA Damage BypassREACTOMER-HSA-73893
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templateREACTOMER-HSA-110313
Translesion synthesis by REV1REACTOMER-HSA-110312
Translesion synthesis by POLKREACTOMER-HSA-5655862
Translesion synthesis by POLIREACTOMER-HSA-5656121
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD
PA445058Neoplasm MetastasisDiseaseClinicalAnnotationassociatedPD
PA445601OsteosarcomaDiseaseClinicalAnnotationassociatedPD
PA448771capecitabineChemicalClinicalAnnotationassociatedPD
PA449014cisplatinChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
334746472021Developmental delay with hypotrophy associated with homozygous functionally relevant REV3L variant.1
336074742021Error-prone bypass patch by a low-fidelity variant of DNA polymerase zeta in human cells.4
336263482021Disruption of DNA polymerase ζ engages an innate immune response.6
345086592021REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps.65
345332262021DNA polymerase zeta contributes to heterochromatin replication to prevent genome instability.6
345975962021The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.11
346559232021REV3L single nucleotide variants lead to increased susceptibility towards non-small cell lung cancer in the population of Jammu and Kashmir.1
334746472021Developmental delay with hypotrophy associated with homozygous functionally relevant REV3L variant.1
336074742021Error-prone bypass patch by a low-fidelity variant of DNA polymerase zeta in human cells.4
336263482021Disruption of DNA polymerase ζ engages an innate immune response.6
345086592021REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps.65
345332262021DNA polymerase zeta contributes to heterochromatin replication to prevent genome instability.6
345975962021The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.11
346559232021REV3L single nucleotide variants lead to increased susceptibility towards non-small cell lung cancer in the population of Jammu and Kashmir.1
318328112020Blood mRNA expression of REV3L and TYMS as potential predictive biomarkers from platinum-based chemotherapy plus pemetrexed in non-small cell lung cancer patients.13

Citation

Dessen P

REV3L (REV3 like, DNA directed polymerase zeta catalytic subunit)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42086/rev3l-(rev3-like-dna-directed-polymerase-zeta-catalytic-subunit)