TRIM13 (tripartite motif containing 13)

2003-02-01  

Identity

HGNC
TRIM13
LOCATION
13q14.2
LOCUSID
10206
ALIAS
CAR,DLEU5,LEU5,RFP2,RNF77
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10206
MIM: 605661
HGNC: 9976
Ensembl: ENSG00000204977

Variants:

dbSNP: 10206
ClinVar: 10206
TCGA: ENSG00000204977
COSMIC: TRIM13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204977ENST00000356017O60858
ENSG00000204977ENST00000378182O60858
ENSG00000204977ENST00000378182A0A024RDU3
ENSG00000204977ENST00000378183X6R9U5
ENSG00000204977ENST00000420995O60858
ENSG00000204977ENST00000420995A0A024RDU3
ENSG00000204977ENST00000442421X6RH27
ENSG00000204977ENST00000457662O60858
ENSG00000204977ENST00000457662A0A024RDU3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
N-glycan trimming in the ER and Calnexin/Calreticulin cycleREACTOMER-HSA-532668
Calnexin/calreticulin cycleREACTOMER-HSA-901042
ER Quality Control Compartment (ERQC)REACTOMER-HSA-901032

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
173144122007The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD.39
221783862012TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells.25
213333772011Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2.21
262882492015Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.17
240212632013TRIM13 regulates caspase-8 ubiquitination, translocation to autophagosomes and activation during ER stress induced cell death.16
245658662014Unveiling the degradative route of the V247M α-sarcoglycan mutant responsible for LGMD-2D.10
251523752014TRIM13 regulates ubiquitination and turnover of NEMO to suppress TNF induced NF-κB activation.8
236474562013TRIM13 (RFP2) downregulation decreases tumour cell growth in multiple myeloma through inhibition of NF Kappa B pathway and proteasome activity.7
164998692006Human RFP2 gene promoter: unique structure and unusual strength.3
302248292018The E3 ubiquitin ligase Trim13 regulates Nur77 stability via casein kinase 2α.2

Citation

Dessen P

TRIM13 (tripartite motif containing 13)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42093/trim13-(tripartite-motif-containing-13)