RHEB (Ras homolog, mTORC1 binding)

2003-02-01  

Identity

HGNC
LOCATION
7q36.1
LOCUSID
ALIAS
RHEB2
FUSION GENES

Other Information

Locus ID:

NCBI: 6009
MIM: 601293
HGNC: 10011
Ensembl: ENSG00000106615

Variants:

dbSNP: 6009
ClinVar: 6009
TCGA: ENSG00000106615
COSMIC: RHEB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106615ENST00000262187Q15382
ENSG00000106615ENST00000262187A0A090N900
ENSG00000106615ENST00000470370C9J469
ENSG00000106615ENST00000472642C9J931
ENSG00000106615ENST00000478470F8WBL3
ENSG00000106615ENST00000496004C9J931

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
mTOR signaling pathwayKEGGko04150
Insulin signaling pathwayKEGGko04910
Autophagy - animalKEGGhsa04140
mTOR signaling pathwayKEGGhsa04150
Insulin signaling pathwayKEGGhsa04910
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Thyroid hormone signaling pathwayKEGGhsa04919
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
Signal TransductionREACTOMER-HSA-162582
Signaling by Insulin receptorREACTOMER-HSA-74752
Insulin receptor signalling cascadeREACTOMER-HSA-74751
IRS-mediated signallingREACTOMER-HSA-112399
PI3K CascadeREACTOMER-HSA-109704
PKB-mediated eventsREACTOMER-HSA-109703
mTOR signallingREACTOMER-HSA-165159
mTORC1-mediated signallingREACTOMER-HSA-166208
Energy dependent regulation of mTOR by LKB1-AMPKREACTOMER-HSA-380972
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)REACTOMER-HSA-2404192
IGF1R signaling cascadeREACTOMER-HSA-2428924
IRS-related events triggered by IGF1RREACTOMER-HSA-2428928
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072
Longevity regulating pathwayKEGGhsa04211

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
128695862003Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.654
158549022005Rheb binds and regulates the mTOR kinase.345
179918642007Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.138
128428882003Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner.123
158788522005Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency.121
186503802008ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo.109
179282952007Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb.93
185508142008Phospholipase D1 is an effector of Rheb in the mTOR pathway.88
153400592004Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity.87
200536792010The late endosome is essential for mTORC1 signaling.79

Citation

Dessen P

RHEB (Ras homolog, mTORC1 binding)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42104/rheb-(ras-homolog-mtorc1-binding)