Identity
HGNC
LOCATION
6p25.2
LOCUSID
ALIAS
AIEFL,IMD57,RIP,RIP-1,RIP1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8737
MIM: 603453
HGNC: 10019
Ensembl: ENSG00000137275
Variants:
dbSNP: 8737
ClinVar: 8737
TCGA: ENSG00000137275
COSMIC: RIPK1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000137275 | ENST00000259808 | Q13546 |
| ENSG00000137275 | ENST00000259808 | A0A024QZU0 |
| ENSG00000137275 | ENST00000380409 | Q13546 |
| ENSG00000137275 | ENST00000380409 | A0A024QZU0 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38227684 | 2024 | Simultaneous substrate and ubiquitin modification recognition by bispecific antibodies enables detection of ubiquitinated RIP1 and RIP2. | 0 |
| 38630344 | 2024 | RIPK3 and RIPK1 gene expression in pterygium: unveiling molecular insights into pathogenesis. | 0 |
| 38632238 | 2024 | TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers. | 0 |
| 38227684 | 2024 | Simultaneous substrate and ubiquitin modification recognition by bispecific antibodies enables detection of ubiquitinated RIP1 and RIP2. | 0 |
| 38630344 | 2024 | RIPK3 and RIPK1 gene expression in pterygium: unveiling molecular insights into pathogenesis. | 0 |
| 38632238 | 2024 | TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers. | 0 |
| 36549711 | 2023 | RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD. | 8 |
| 36634793 | 2023 | Upregulation of RIPK1 implicates in HEK 293T cell death upon transient transfection of A53T-α-synuclein. | 0 |
| 36997719 | 2023 | RNF31 promotes tumorigenesis via inhibiting RIPK1 kinase-dependent apoptosis. | 1 |
| 37085671 | 2023 | IKK-mediated TRAF6 and RIPK1 interaction stifles cell death complex assembly leading to the suppression of TNF-α-induced cell death. | 1 |
| 37217473 | 2023 | RIPK1-dependent necroptosis promotes vasculogenic mimicry formation via eIF4E in triple-negative breast cancer. | 6 |
| 37359541 | 2023 | O-GlcNAcylation of RIPK1 rescues red blood cells from necroptosis. | 2 |
| 37828624 | 2023 | Caspase 6 promotes innate immune activation by functional crosstalk between RIPK1-IκBα axis in liver inflammation. | 1 |
| 38086800 | 2023 | Elevated peripheral levels of receptor-interacting protein kinase 1 (RIPK1) and IL-8 as biomarkers of human amyotrophic lateral sclerosis. | 0 |
| 36549711 | 2023 | RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD. | 8 |
Citation
Dessen P
RIPK1 (receptor interacting serine/threonine kinase 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/42119/ripk1-(receptor-interacting-serine-threonine-kinase-1)
