RIPK2 (receptor interacting serine/threonine kinase 2)

2003-06-01  

Identity

HGNC
LOCATION
8q21.3
LOCUSID
ALIAS
CARD3,CARDIAK,CCK,GIG30,RICK,RIP2
FUSION GENES

Other Information

Locus ID:

NCBI: 8767
MIM: 603455
HGNC: 10020
Ensembl: ENSG00000104312

Variants:

dbSNP: 8767
ClinVar: 8767
TCGA: ENSG00000104312
COSMIC: RIPK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104312ENST00000220751O43353
ENSG00000104312ENST00000220751A0A0S2Z4Z8
ENSG00000104312ENST00000517696E5RGK6
ENSG00000104312ENST00000522965E7ERW9

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
ShigellosisKEGGhsa05131
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
TCR signalingREACTOMER-HSA-202403
Downstream TCR signalingREACTOMER-HSA-202424
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 10 (TLR10) CascadeREACTOMER-HSA-168142
MyD88 cascade initiated on plasma membraneREACTOMER-HSA-975871
TAK1 activates NFkB by phosphorylation and activation of IKKs complexREACTOMER-HSA-445989
MAP kinase activation in TLR cascadeREACTOMER-HSA-450294
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1REACTOMER-HSA-450321
activated TAK1 mediates p38 MAPK activationREACTOMER-HSA-450302
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
Toll Like Receptor 5 (TLR5) CascadeREACTOMER-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) CascadeREACTOMER-HSA-168181
MyD88 dependent cascade initiated on endosomeREACTOMER-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationREACTOMER-HSA-975138
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
MyD88:Mal cascade initiated on plasma membraneREACTOMER-HSA-166058
Toll Like Receptor 2 (TLR2) CascadeREACTOMER-HSA-181438
Toll Like Receptor TLR1:TLR2 CascadeREACTOMER-HSA-168179
Toll Like Receptor TLR6:TLR2 CascadeREACTOMER-HSA-168188
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysREACTOMER-HSA-168643
NOD1/2 Signaling PathwayREACTOMER-HSA-168638
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-1 signalingREACTOMER-HSA-446652
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
p75NTR signals via NF-kBREACTOMER-HSA-193639
p75NTR recruits signalling complexesREACTOMER-HSA-209543
DeubiquitinationREACTOMER-HSA-5688426
Ovarian tumor domain proteasesREACTOMER-HSA-5689896

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
118940982002RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems.258
200189612009Genomewide association study of leprosy.241
180796942008A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation.172
156206482004The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO.131
196672032009XIAP mediates NOD signaling via interaction with RIP2.109
118940972002Involvement of receptor-interacting protein 2 in innate and adaptive immune responses.100
247465522014The immune receptor NOD1 and kinase RIP2 interact with bacterial peptidoglycan on early endosomes to promote autophagy and inflammatory signaling.69
211236522010Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses.67
173559682007The NOD2-RICK complex signals from the plasma membrane.47
170549812007Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK.37

Citation

Dessen P

RIPK2 (receptor interacting serine/threonine kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42120/ripk2-(receptor-interacting-serine-threonine-kinase-2)