RNF40 (ring finger protein 40)

2003-10-01  

Identity

HGNC
LOCATION
16p11.2
LOCUSID
ALIAS
BRE1B,RBP95,STARING
FUSION GENES

Other Information

Locus ID:

NCBI: 9810
MIM: 607700
HGNC: 16867
Ensembl: ENSG00000103549

Variants:

dbSNP: 9810
ClinVar: 9810
TCGA: ENSG00000103549
COSMIC: RNF40

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103549ENST00000324685O75150
ENSG00000103549ENST00000357890O75150
ENSG00000103549ENST00000563683H3BP71
ENSG00000103549ENST00000563909H3BQ99
ENSG00000103549ENST00000565931I3L332
ENSG00000103549ENST00000565995H3BS50
ENSG00000103549ENST00000566811H3BUL6
ENSG00000103549ENST00000567365A0A087WTK2
ENSG00000103549ENST00000602784R4GN66

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Protein ubiquitinationREACTOMER-HSA-8852135
E3 ubiquitin ligases ubiquitinate target proteinsREACTOMER-HSA-8866654

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
385178922024Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes.0
385178922024Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes.0
377704352023RNF40 epigenetically modulates glycolysis to support the aggressiveness of basal-like breast cancer.1
377704352023RNF40 epigenetically modulates glycolysis to support the aggressiveness of basal-like breast cancer.1
331998252021Epigenetic modification and a role for the E3 ligase RNF40 in cancer development and metastasis.20
331998252021Epigenetic modification and a role for the E3 ligase RNF40 in cancer development and metastasis.20
311526612020The RNF20/40 complex regulates p53-dependent gene transcription and mRNA splicing.15
323413582020The H2B ubiquitin-protein ligase RNF40 is required for somatic cell reprogramming.13
330701552020The histone H2B ubiquitin ligase RNF40 is required for HER2-driven mammary tumorigenesis.8
311526612020The RNF20/40 complex regulates p53-dependent gene transcription and mRNA splicing.15
323413582020The H2B ubiquitin-protein ligase RNF40 is required for somatic cell reprogramming.13
330701552020The histone H2B ubiquitin ligase RNF40 is required for HER2-driven mammary tumorigenesis.8
303213252019Loss of RNF40 Decreases NF-κB Activity in Colorectal Cancer Cells and Reduces Colitis Burden in Mice.19
306494292019RNF20/40-mediated eEF1BδL monoubiquitylation stimulates transcription of heat shock-responsive genes.11
312665412019The E3 ubiquitin ligase RNF40 suppresses apoptosis in colorectal cancer cells.15

Citation

Dessen P

RNF40 (ring finger protein 40)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/42138/rnf40-(ring-finger-protein-40)