RPL23 (ribosomal protein L23)

2003-05-01  

Identity

HGNC
LOCATION
17q12
LOCUSID
ALIAS
L23,rpL17
FUSION GENES

Other Information

Locus ID:

NCBI: 9349
MIM: 603662
HGNC: 10316
Ensembl: ENSG00000125691

Variants:

dbSNP: 9349
ClinVar: 9349
TCGA: ENSG00000125691
COSMIC: RPL23

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125691ENST00000245857J3KTJ3
ENSG00000125691ENST00000378096C9JD32
ENSG00000125691ENST00000394332P62829
ENSG00000125691ENST00000394332A0A024R1Q8
ENSG00000125691ENST00000394333B9ZVP7
ENSG00000125691ENST00000470646J3QQT9
ENSG00000125691ENST00000479035P62829
ENSG00000125691ENST00000479035A0A024R1Q8
ENSG00000125691ENST00000577407J3KT29

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
RibosomeKEGGko03010
RibosomeKEGGhsa03010
Ribosome, eukaryotesKEGGhsa_M00177
Ribosome, eukaryotesKEGGM00177
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Formation of a pool of free 40S subunitsREACTOMER-HSA-72689
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Eukaryotic Translation ElongationREACTOMER-HSA-156842
Peptide chain elongationREACTOMER-HSA-156902
Eukaryotic Translation TerminationREACTOMER-HSA-72764
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Influenza InfectionREACTOMER-HSA-168254
Influenza Life CycleREACTOMER-HSA-168255
Influenza Viral RNA Transcription and ReplicationREACTOMER-HSA-168273
Viral mRNA TranslationREACTOMER-HSA-192823
Gene ExpressionREACTOMER-HSA-74160
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)REACTOMER-HSA-975956
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Selenoamino acid metabolismREACTOMER-HSA-2408522
Selenocysteine synthesisREACTOMER-HSA-2408557
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
285396032017Ribosomal protein L23 negatively regulates cellular apoptosis via the RPL23/Miz-1/c-Myc circuit in higher-risk myelodysplastic syndrome.23
285396032017Ribosomal protein L23 negatively regulates cellular apoptosis via the RPL23/Miz-1/c-Myc circuit in higher-risk myelodysplastic syndrome.23
260446512015Growth inhibitory effect of adenovirus-mediated tissue-targeted expression of ribosomal protein L23 on human colorectal carcinoma cells.1
260446512015Growth inhibitory effect of adenovirus-mediated tissue-targeted expression of ribosomal protein L23 on human colorectal carcinoma cells.1
231603752013A novel approach to biomarker discovery in head and neck cancer using an autoantibody signature.11
239338262013Co-transduction of ribosomal protein L23 enhances the therapeutic efficacy of adenoviral-mediated p53 gene transfer in human gastric cancer.14
231603752013A novel approach to biomarker discovery in head and neck cancer using an autoantibody signature.11
239338262013Co-transduction of ribosomal protein L23 enhances the therapeutic efficacy of adenoviral-mediated p53 gene transfer in human gastric cancer.14
225807512012Over-expression of RPL23 in myelodysplastic syndromes is associated with apoptosis resistance of CD34+ cells and predicts poor prognosis and distinct response to CHG chemotherapy or decitabine.9
225807512012Over-expression of RPL23 in myelodysplastic syndromes is associated with apoptosis resistance of CD34+ cells and predicts poor prognosis and distinct response to CHG chemotherapy or decitabine.9
191604852008A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth.55
191604852008A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth.55
151498632004Ribosomal proteins S13 and L23 promote multidrug resistance in gastric cancer cells by suppressing drug-induced apoptosis.47
153086432004Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5.276
153141732004Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition.255

Citation

Dessen P

RPL23 (ribosomal protein L23)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42151/rpl23-(ribosomal-protein-l23)