RPS15 (ribosomal protein S15)

2003-06-01 Affiliation

Identity

HGNC

RPS15

LOCATION

19p13.3

LOCUSID

6209

ALIAS

RIG,S15

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6209
MIM: 180535
HGNC: 10388
Ensembl: ENSG00000115268

Variants:

dbSNP: 6209
ClinVar: 6209
TCGA: ENSG00000115268
COSMIC: RPS15

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000115268	ENST00000233609	A0A0B4J2B4
ENSG00000115268	ENST00000585665	K7EM56
ENSG00000115268	ENST00000586096	K7EJ78
ENSG00000115268	ENST00000586656	S4R456
ENSG00000115268	ENST00000586686	K7EM56
ENSG00000115268	ENST00000589656	K7EQJ5
ENSG00000115268	ENST00000591032	S4R417
ENSG00000115268	ENST00000591804	K7EM56
ENSG00000115268	ENST00000592588	P62841
ENSG00000115268	ENST00000592623	A0A0B4J2B4
ENSG00000115268	ENST00000593052	K7ELC2
ENSG00000115268	ENST00000617694	A0A1Y8EIB3

Expression (GTEx)

500

1000

1500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Ribosome	KEGG	ko03010
Ribosome	KEGG	hsa03010
Ribosome, eukaryotes	KEGG	hsa_M00177
Ribosome, eukaryotes	KEGG	M00177
Metabolism of proteins	REACTOME	R-HSA-392499
Translation	REACTOME	R-HSA-72766
Eukaryotic Translation Initiation	REACTOME	R-HSA-72613
Cap-dependent Translation Initiation	REACTOME	R-HSA-72737
Formation of a pool of free 40S subunits	REACTOME	R-HSA-72689
Formation of the ternary complex, and subsequently, the 43S complex	REACTOME	R-HSA-72695
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	REACTOME	R-HSA-72662
Translation initiation complex formation	REACTOME	R-HSA-72649
Ribosomal scanning and start codon recognition	REACTOME	R-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunit	REACTOME	R-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expression	REACTOME	R-HSA-156827
SRP-dependent cotranslational protein targeting to membrane	REACTOME	R-HSA-1799339
Eukaryotic Translation Elongation	REACTOME	R-HSA-156842
Peptide chain elongation	REACTOME	R-HSA-156902
Eukaryotic Translation Termination	REACTOME	R-HSA-72764
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
Influenza Infection	REACTOME	R-HSA-168254
Influenza Life Cycle	REACTOME	R-HSA-168255
Influenza Viral RNA Transcription and Replication	REACTOME	R-HSA-168273
Viral mRNA Translation	REACTOME	R-HSA-192823
Gene Expression	REACTOME	R-HSA-74160
Nonsense-Mediated Decay (NMD)	REACTOME	R-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	REACTOME	R-HSA-975957
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	REACTOME	R-HSA-975956
Metabolism	REACTOME	R-HSA-1430728
Metabolism of amino acids and derivatives	REACTOME	R-HSA-71291
Selenoamino acid metabolism	REACTOME	R-HSA-2408522
Selenocysteine synthesis	REACTOME	R-HSA-2408557
rRNA processing	REACTOME	R-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosol	REACTOME	R-HSA-6791226
rRNA processing in the nucleus and cytosol	REACTOME	R-HSA-8868773

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37264021	2023	RPS15 interacted with IGF2BP1 to promote esophageal squamous cell carcinoma development via recognizing m(6)A modification.	5
37603533	2023	The value of RPS15 and MRPS27 in ischemic stroke.	1
37264021	2023	RPS15 interacted with IGF2BP1 to promote esophageal squamous cell carcinoma development via recognizing m(6)A modification.	5
37603533	2023	The value of RPS15 and MRPS27 in ischemic stroke.	1
35438042	2022	The C-terminal tail of ribosomal protein Rps15 is engaged in cytoplasmic pre-40S maturation.	3
35438042	2022	The C-terminal tail of ribosomal protein Rps15 is engaged in cytoplasmic pre-40S maturation.	3
34251413	2021	RPS15 mutations rewire RNA translation in chronic lymphocytic leukemia.	10
34251413	2021	RPS15 mutations rewire RNA translation in chronic lymphocytic leukemia.	10
31802126	2020	mRNA regions where 80S ribosomes pause during translation elongation in vivo interact with protein uS19, a component of the decoding site.	7
31991215	2020	The functional role of the C-terminal tail of the human ribosomal protein uS19.	2
31802126	2020	mRNA regions where 80S ribosomes pause during translation elongation in vivo interact with protein uS19, a component of the decoding site.	7
31991215	2020	The functional role of the C-terminal tail of the human ribosomal protein uS19.	2
30181176	2018	Altered patterns of global protein synthesis and translational fidelity in RPS15-mutated chronic lymphocytic leukemia.	33
30181176	2018	Altered patterns of global protein synthesis and translational fidelity in RPS15-mutated chronic lymphocytic leukemia.	33
26675346	2016	Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations.	84

Citation

Dessen P

RPS15 (ribosomal protein S15)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42162/rps15-(ribosomal-protein-s15)