RPS6KA2 (ribosomal protein S6 kinase A2)

2003-11-01  

Identity

HGNC
LOCATION
6q27
LOCUSID
ALIAS
HU-2,MAPKAPK1C,RSK,RSK3,S6K-alpha,S6K-alpha2,p90-RSK3,p90RSK2,pp90RSK3
FUSION GENES

Other Information

Locus ID:

NCBI: 6196
MIM: 601685
HGNC: 10431
Ensembl: ENSG00000071242

Variants:

dbSNP: 6196
ClinVar: 6196
TCGA: ENSG00000071242
COSMIC: RPS6KA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000071242ENST00000265678Q15349
ENSG00000071242ENST00000405189B7Z3B5
ENSG00000071242ENST00000481261B7Z3B5
ENSG00000071242ENST00000503859Q15349
ENSG00000071242ENST00000506565D6RE03
ENSG00000071242ENST00000507350D6R910
ENSG00000071242ENST00000507371D6RA62
ENSG00000071242ENST00000510118F2Z2J1
ENSG00000071242ENST00000511034D6RD75
ENSG00000071242ENST00000512860D6RHW7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
mTOR signaling pathwayKEGGko04150
Long-term potentiationKEGGko04720
Progesterone-mediated oocyte maturationKEGGko04914
MAPK signaling pathwayKEGGhsa04010
mTOR signaling pathwayKEGGhsa04150
Long-term potentiationKEGGhsa04720
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
Progesterone-mediated oocyte maturationKEGGhsa04914
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Activation of NMDA receptor upon glutamate binding and postsynaptic eventsREACTOMER-HSA-442755
Post NMDA receptor activation eventsREACTOMER-HSA-438064
CREB phosphorylation through the activation of RasREACTOMER-HSA-442742
RSK activationREACTOMER-HSA-444257
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 10 (TLR10) CascadeREACTOMER-HSA-168142
MyD88 cascade initiated on plasma membraneREACTOMER-HSA-975871
MAP kinase activation in TLR cascadeREACTOMER-HSA-450294
MAPK targets/ Nuclear events mediated by MAP kinasesREACTOMER-HSA-450282
ERK/MAPK targetsREACTOMER-HSA-198753
CREB phosphorylationREACTOMER-HSA-199920
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
Toll Like Receptor 5 (TLR5) CascadeREACTOMER-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) CascadeREACTOMER-HSA-168181
MyD88 dependent cascade initiated on endosomeREACTOMER-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationREACTOMER-HSA-975138
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
MyD88:Mal cascade initiated on plasma membraneREACTOMER-HSA-166058
Toll Like Receptor 2 (TLR2) CascadeREACTOMER-HSA-181438
Toll Like Receptor TLR1:TLR2 CascadeREACTOMER-HSA-168179
Toll Like Receptor TLR6:TLR2 CascadeREACTOMER-HSA-168188
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Nuclear Events (kinase and transcription factor activation)REACTOMER-HSA-198725
Signaling by GPCRREACTOMER-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760
Recycling pathway of L1REACTOMER-HSA-437239
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Senescence-Associated Secretory Phenotype (SASP)REACTOMER-HSA-2559582
Insulin resistanceKEGGhsa04931

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
168781542007RPS6KA2, a putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer.38
236357762013RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer.36
166266232006The MAP kinase ERK5 binds to and phosphorylates p90 RSK.29
210354692011Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer.23
210354692011Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer.23
166218052006Hdm2 nuclear export, regulated by insulin-like growth factor-I/MAPK/p90Rsk signaling, mediates the transformation of human cells.20
120162172002Characterization of the p90 ribosomal S6 kinase 2 carboxyl-terminal domain as a protein kinase.17
168959152006Nuclear export of S6K1 II is regulated by protein kinase CK2 phosphorylation at Ser-17.15
215275142011p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia.10

Citation

Dessen P

RPS6KA2 (ribosomal protein S6 kinase A2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42167/rps6ka2-(ribosomal-protein-s6-kinase-a2)