Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6237
MIM: 165090
HGNC: 10447
Ensembl: ENSG00000126458
Variants:
dbSNP: 6237
ClinVar: 6237
TCGA: ENSG00000126458
COSMIC: RRAS
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000126458 | ENST00000246792 | P10301 |
| ENSG00000126458 | ENST00000246792 | A0A024QZF2 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA24928 | ARAF | Gene | Pathway | associated | |||
| PA25408 | BRAF | Gene | Pathway | associated | |||
| PA30592 | MAP3K1 | Gene | Pathway | associated | |||
| PA34183 | RAF1 | Gene | Pathway | associated | |||
| PA7360 | EGFR | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38383288 | 2024 | The ancestral type of the R-RAS protein has oncogenic potential. | 0 |
| 38383288 | 2024 | The ancestral type of the R-RAS protein has oncogenic potential. | 0 |
| 36960869 | 2023 | METTL3/YTHDF2 m6A axis promotes the malignant progression of bladder cancer by epigenetically suppressing RRAS. | 3 |
| 36960869 | 2023 | METTL3/YTHDF2 m6A axis promotes the malignant progression of bladder cancer by epigenetically suppressing RRAS. | 3 |
| 34530870 | 2021 | R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells. | 6 |
| 34530870 | 2021 | R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells. | 6 |
| 28263956 | 2017 | SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras. | 59 |
| 28263956 | 2017 | SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras. | 59 |
| 26993606 | 2016 | Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation. | 13 |
| 27270312 | 2016 | Quantitative proteomics reveals that distant recurrence-associated protein R-Ras and Transgelin predict post-surgical survival in patients with Stage III colorectal cancer. | 12 |
| 26993606 | 2016 | Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation. | 13 |
| 27270312 | 2016 | Quantitative proteomics reveals that distant recurrence-associated protein R-Ras and Transgelin predict post-surgical survival in patients with Stage III colorectal cancer. | 12 |
| 25447204 | 2015 | OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity. | 44 |
| 25869066 | 2015 | Girdin/GIV regulates transendothelial permeability by controlling VE-cadherin trafficking through the small GTPase, R-Ras. | 13 |
| 26381333 | 2015 | miR-34/449 control apical actin network formation during multiciliogenesis through small GTPase pathways. | 30 |
Citation
Dessen P
RRAS (RAS related)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/42172/rras
