Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 22800
MIM: 600098
HGNC: 17271
Ensembl: ENSG00000133818
Variants:
dbSNP: 22800
ClinVar: 22800
TCGA: ENSG00000133818
COSMIC: RRAS2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443560 | Breast Neoplasms | Disease | ClinicalAnnotation | associated | PD | 19047159 | |
| PA451581 | tamoxifen | Chemical | ClinicalAnnotation | associated | PD | 19047159 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37942564 | 2024 | The RRAS2 pathogenic variant (c.67G>T; p. Gly23Cys) produces Noonan syndrome with embryonal rhabdomyosarcoma. | 1 |
| 37942564 | 2024 | The RRAS2 pathogenic variant (c.67G>T; p. Gly23Cys) produces Noonan syndrome with embryonal rhabdomyosarcoma. | 1 |
| 36476833 | 2023 | Characterization of mutant versions of the R-RAS2/TC21 GTPase found in tumors. | 3 |
| 37423552 | 2023 | MicroRNA-23b Plays a Tumor-Suppressive Role in Cutaneous Squamous Cell Carcinoma and Targets Ras-Related Protein RRAS2. | 2 |
| 38067115 | 2023 | Characterization of Three Somatic Mutations in the 3'UTR of RRAS2 and Their Inverse Correlation with Lymphocytosis in Chronic Lymphocytic Leukemia. | 1 |
| 36476833 | 2023 | Characterization of mutant versions of the R-RAS2/TC21 GTPase found in tumors. | 3 |
| 37423552 | 2023 | MicroRNA-23b Plays a Tumor-Suppressive Role in Cutaneous Squamous Cell Carcinoma and Targets Ras-Related Protein RRAS2. | 2 |
| 38067115 | 2023 | Characterization of Three Somatic Mutations in the 3'UTR of RRAS2 and Their Inverse Correlation with Lymphocytosis in Chronic Lymphocytic Leukemia. | 1 |
| 34530870 | 2021 | R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells. | 6 |
| 34530870 | 2021 | R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells. | 6 |
| 31130282 | 2019 | Activating Mutations of RRAS2 Are a Rare Cause of Noonan Syndrome. | 29 |
| 31130285 | 2019 | Germline-Activating RRAS2 Mutations Cause Noonan Syndrome. | 21 |
| 31517733 | 2019 | RRAS2 knockdown suppresses osteosarcoma progression by inactivating the MEK/ERK signaling pathway. | 2 |
| 31130282 | 2019 | Activating Mutations of RRAS2 Are a Rare Cause of Noonan Syndrome. | 29 |
| 31130285 | 2019 | Germline-Activating RRAS2 Mutations Cause Noonan Syndrome. | 21 |
Citation
Dessen P
RRAS2 (RAS related 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/42173
