RRAS2 (RAS related 2)

2003-02-01  

Identity

HGNC
RRAS2
LOCATION
11p15.2
LOCUSID
22800
ALIAS
NS12,TC21
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22800
MIM: 600098
HGNC: 17271
Ensembl: ENSG00000133818

Variants:

dbSNP: 22800
ClinVar: 22800
TCGA: ENSG00000133818
COSMIC: RRAS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133818ENST00000256196P62070
ENSG00000133818ENST00000414023P62070
ENSG00000133818ENST00000526063P62070
ENSG00000133818ENST00000526717E9PQC5
ENSG00000133818ENST00000529237P62070
ENSG00000133818ENST00000531421E9PQ87
ENSG00000133818ENST00000531807E9PK85
ENSG00000133818ENST00000532814P62070
ENSG00000133818ENST00000532950E9PQK5
ENSG00000133818ENST00000534746P62070
ENSG00000133818ENST00000537760P62070

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Autophagy - animalKEGGko04140
Regulation of actin cytoskeletonKEGGko04810
MAPK signaling pathwayKEGGhsa04010
Autophagy - animalKEGGhsa04140
Regulation of actin cytoskeletonKEGGhsa04810
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Ras signaling pathwayKEGGhsa04014
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072
Apelin signaling pathwayKEGGhsa04371
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD19047159
PA451581tamoxifenChemicalClinicalAnnotationassociatedPD19047159

References

Pubmed IDYearTitleCitations
195616132009Essential function for the GTPase TC21 in homeostatic antigen receptor signaling.41
279360462016The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding Regions.14
176563622007Signaling pathways regulating TC21-induced tumorigenesis.12
186289882008Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease.9
217810672011Greater expression of TC21/R-ras2 in highly aggressive malignant skin cancer.9
248268672014Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease.8
210851262011SNPs in axon guidance pathway genes and susceptibility for Parkinson's disease in the Korean population.7
190471592008A polymorphism in the TC21 promoter associates with an unfavorable tamoxifen treatment outcome in breast cancer.6
241485642013R-RAS2 overexpression in tumors of the human central nervous system.6
208117072010TC21 promotes cell motility and metastasis by regulating the expression of E-cadherin and N-cadherin in hepatocellular carcinoma.5

Citation

Dessen P

RRAS2 (RAS related 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42173/rras2-(ras-related-2)