CLIP1 (CAP-Gly domain containing linker protein 1)

2003-02-01 Affiliation

Identity

HGNC

CLIP1

LOCATION

12q24.31

LOCUSID

6249

ALIAS

CLIP,CLIP-170,CLIP170,CYLN1,RSN

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6249
MIM: 179838
HGNC: 10461
Ensembl: ENSG00000130779

Variants:

dbSNP: 6249
ClinVar: 6249
TCGA: ENSG00000130779
COSMIC: CLIP1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000130779	ENST00000302528	P30622
ENSG00000130779	ENST00000302528	A0A024RBR1
ENSG00000130779	ENST00000358808	P30622
ENSG00000130779	ENST00000358808	A0A024RBR1
ENSG00000130779	ENST00000361654	J3KP58
ENSG00000130779	ENST00000535290	F5H270
ENSG00000130779	ENST00000536634	A0A3B3IS27
ENSG00000130779	ENST00000537123	A0A3B3ISJ8
ENSG00000130779	ENST00000537178	P30622
ENSG00000130779	ENST00000539080	F5H367
ENSG00000130779	ENST00000540304	F5H6A0
ENSG00000130779	ENST00000540338	P30622
ENSG00000130779	ENST00000541108	F5H1T5
ENSG00000130779	ENST00000545889	F5H0N7
ENSG00000130779	ENST00000620786	P30622
ENSG00000130779	ENST00000648993	A0A3B3ITA2

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
mTOR signaling pathway	KEGG	ko04150
mTOR signaling pathway	KEGG	hsa04150
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Rho GTPases	REACTOME	R-HSA-194315
RHO GTPase Effectors	REACTOME	R-HSA-195258
RHO GTPases activate IQGAPs	REACTOME	R-HSA-5626467
RHO GTPases Activate Formins	REACTOME	R-HSA-5663220
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
M Phase	REACTOME	R-HSA-68886
Mitotic Prometaphase	REACTOME	R-HSA-68877
Resolution of Sister Chromatid Cohesion	REACTOME	R-HSA-2500257
Mitotic Metaphase and Anaphase	REACTOME	R-HSA-2555396
Mitotic Anaphase	REACTOME	R-HSA-68882
Separation of Sister Chromatids	REACTOME	R-HSA-2467813

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
12110184	2002	Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170.	213
17889670	2007	Structural basis of microtubule plus end tracking by XMAP215, CLIP-170, and EB1.	120
11940666	2002	LIS1, CLIP-170's key to the dynein/dynactin pathway.	94
19126680	2009	Microtubule plus-end tracking by CLIP-170 requires EB1.	86
17828277	2007	Structure-function relationship of CAP-Gly domains.	73
19020519	2008	Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly.	71
17563362	2007	Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition.	46
16772339	2006	Microtubule plus-end loading of p150(Glued) is mediated by EB1 and CLIP-170 but is not required for intracellular membrane traffic in mammalian cells.	44
27199431	2016	Accelerated actin filament polymerization from microtubule plus ends.	44
20664522	2010	Phosphorylation of CLIP-170 by Plk1 and CK2 promotes timely formation of kinetochore-microtubule attachments.	40

Citation

Dessen P

CLIP1 (CAP-Gly domain containing linker protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42178/clip1-(cap-gly-domain-containing-linker-protein-1)