SAFB (scaffold attachment factor B)

2003-06-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
HAP,HET,SAB-B1,SAF-B,SAF-B1,SAFB1
FUSION GENES

Other Information

Locus ID:

NCBI: 6294
MIM: 602895
HGNC: 10520
Ensembl: ENSG00000160633

Variants:

dbSNP: 6294
ClinVar: 6294
TCGA: ENSG00000160633
COSMIC: SAFB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160633ENST00000292123Q15424
ENSG00000160633ENST00000454510Q15424
ENSG00000160633ENST00000588852Q15424
ENSG00000160633ENST00000589006K7EII0
ENSG00000160633ENST00000589863K7ES42
ENSG00000160633ENST00000592224Q15424

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
240553462013The chromatin scaffold protein SAFB1 renders chromatin permissive for DNA damage signaling.28
161952512006Scaffold attachment factor SAFB1 suppresses estrogen receptor alpha-mediated transcription in part via interaction with nuclear receptor corepressor.27
145870242003Scaffold attachment factors SAFB1 and SAFB2: Innocent bystanders or critical players in breast tumorigenesis?25
150669972004Structure-function analysis of the estrogen receptor alpha corepressor scaffold attachment factor-B1: identification of a potent transcriptional repression domain.24
164751612006Role of protein phosphatase 2A in the regulation of endothelial cell cytoskeleton structure.22
128372812003Nuclear speckle localisation of the small heat shock protein alpha B-crystallin and its inhibition by the R120G cardiomyopathy-linked mutation.16
163268362005Scaffold attachment factor B1 directly interacts with nuclear receptors in living cells and represses transcriptional activity.15
191374252010Low SAFB levels are associated with worse outcome in breast cancer patients.13
199010292010SAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells.12
187721452008Identification of proteins binding to E-Box/Ku86 sites and function of the tumor suppressor SAFB1 in transcriptional regulation of the human xanthine oxidoreductase gene.10

Citation

Dessen P

SAFB (scaffold attachment factor B)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42197/safb-(scaffold-attachment-factor-b)