SCRIB (scribble planar cell polarity protein)

2003-02-01  

Identity

HGNC
LOCATION
8q24.3
LOCUSID
ALIAS
CRIB1,SCRB1,SCRIB1,Vartul
FUSION GENES

Other Information

Locus ID:

NCBI: 23513
MIM: 607733
HGNC: 30377
Ensembl: ENSG00000180900

Variants:

dbSNP: 23513
ClinVar: 23513
TCGA: ENSG00000180900
COSMIC: SCRIB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180900ENST00000320476Q14160
ENSG00000180900ENST00000356994Q14160
ENSG00000180900ENST00000377533Q14160
ENSG00000180900ENST00000526832H0YCG0
ENSG00000180900ENST00000531942H0YDF9

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Tight junctionKEGGhsa04530
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
PCP/CE pathwayREACTOMER-HSA-4086400
Asymmetric localization of PCP proteinsREACTOMER-HSA-4608870

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
190417502008Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma.183
110272932000Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase.151
163443082005The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin.123
158061482005Junctional recruitment of mammalian Scribble relies on E-cadherin engagement.82
170436542007The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge.79
219653292011SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia.61
186416852008Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling.60
220955312012Mutations in the planar cell polarity genes CELSR1 and SCRIB are associated with the severe neural tube defect craniorachischisis.52
161038862005The hScrib/Dlg apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteins.47
180422582008Tick-borne encephalitis virus NS5 associates with membrane protein scribble and impairs interferon-stimulated JAK-STAT signalling.46

Citation

Dessen P

SCRIB (scribble planar cell polarity protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42218/scrib-(scribble-planar-cell-polarity-protein)