EXOC2 (exocyst complex component 2)

2004-02-01  

Identity

HGNC
EXOC2
LOCATION
6p25.3
LOCUSID
55770
ALIAS
NEDFACH,SEC5,SEC5L1,Sec5p
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55770
MIM: 615329
HGNC: 24968
Ensembl: ENSG00000112685

Variants:

dbSNP: 55770
ClinVar: 55770
TCGA: ENSG00000112685
COSMIC: EXOC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112685ENST00000230449Q96KP1
ENSG00000112685ENST00000230449A0A024QZT2
ENSG00000112685ENST00000443083Q2MDF5

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ras signaling pathwayKEGGhsa04014
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Insulin processingREACTOMER-HSA-264876
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
VxPx cargo-targeting to ciliumREACTOMER-HSA-5620916
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148

References

Pubmed IDYearTitleCitations
326395402020Mutations in the exocyst component EXOC2 cause severe defects in human brain development.15
326395402020Mutations in the exocyst component EXOC2 cause severe defects in human brain development.15
263593012015Dexamethasone-induced cellular tension requires a SGK1-stimulated Sec5-GEF-H1 interaction.8
263593012015Dexamethasone-induced cellular tension requires a SGK1-stimulated Sec5-GEF-H1 interaction.8
238440302013Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion.10
238440302013Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion.10
227618372012Sec5 and Exo84 mediate distinct aspects of RalA-dependent cell polarization.10
227618372012Sec5 and Exo84 mediate distinct aspects of RalA-dependent cell polarization.10
211976182011Model-based prediction of human hair color using DNA variants.35
211976182011Model-based prediction of human hair color using DNA variants.35
201450372010Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis.22
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
205709662010Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.181
206165602010Genetic differences between five European populations.18
201450372010Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis.22

Citation

Dessen P

EXOC2 (exocyst complex component 2)

Atlas Genet Cytogenet Oncol Haematol. 2004-02-01

Online version: http://atlasgeneticsoncology.org/gene/42239/js/lib/favicon/welcome