SEC63 (SEC63 homolog, protein translocation regulator)

2003-06-01   Dessen P  

Identity

HGNC
SEC63
LOCATION
6q21
LOCUSID
11231
ALIAS
DNAJC23,ERdj2,PCLD2,PRO2507,SEC63L
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11231
MIM: 608648
HGNC: 21082
Ensembl: ENSG00000025796

Variants:

dbSNP: 11231
ClinVar: 11231
TCGA: ENSG00000025796
COSMIC: SEC63

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000025796ENST00000369002Q9UGP8
ENSG00000025796ENST00000369002A0A0S2Z5M1
ENSG00000025796ENST00000429168A6PVC9
ENSG00000025796ENST00000446496F8WB27

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein exportKEGGko03060
Protein exportKEGGhsa03060
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
371220032023Activation of ACLY by SEC63 deploys metabolic reprogramming to facilitate hepatocellular carcinoma metastasis upon endoplasmic reticulum stress.7
371220032023Activation of ACLY by SEC63 deploys metabolic reprogramming to facilitate hepatocellular carcinoma metastasis upon endoplasmic reticulum stress.7
344294512021Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth.8
344294512021Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth.8
321337892020Identification of signal peptide features for substrate specificity in human Sec62/Sec63-dependent ER protein import.22
333786672020A Molecular Mechanism for Turning Off IRE1α Signaling during Endoplasmic Reticulum Stress.25
321337892020Identification of signal peptide features for substrate specificity in human Sec62/Sec63-dependent ER protein import.22
333786672020A Molecular Mechanism for Turning Off IRE1α Signaling during Endoplasmic Reticulum Stress.25
289735242017Liver cyst gene knockout in cholangiocytes inhibits cilium formation and Wnt signaling.2
289735242017Liver cyst gene knockout in cholangiocytes inhibits cilium formation and Wnt signaling.2
232875492013CK2 phosphorylation of human Sec63 regulates its interaction with Sec62.9
232875492013CK2 phosphorylation of human Sec63 regulates its interaction with Sec62.9
223750592012Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells.80
231666192012Role of human sec63 in modulating the steady-state levels of multi-spanning membrane proteins.7
232097132012Loss of heterozygosity is present in SEC63 germline carriers with polycystic liver disease.17

Citation

Dessen P

SEC63 (SEC63 homolog, protein translocation regulator)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42242/sec63-(sec63-homolog-protein-translocation-regulator)