Identity
HGNC
LOCATION
6q21
LOCUSID
ALIAS
DNAJC23,ERdj2,PCLD2,PRO2507,SEC63L
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 11231
MIM: 608648
HGNC: 21082
Ensembl: ENSG00000025796
Variants:
dbSNP: 11231
ClinVar: 11231
TCGA: ENSG00000025796
COSMIC: SEC63
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000025796 | ENST00000369002 | Q9UGP8 |
| ENSG00000025796 | ENST00000369002 | A0A0S2Z5M1 |
| ENSG00000025796 | ENST00000429168 | A6PVC9 |
| ENSG00000025796 | ENST00000446496 | F8WB27 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37122003 | 2023 | Activation of ACLY by SEC63 deploys metabolic reprogramming to facilitate hepatocellular carcinoma metastasis upon endoplasmic reticulum stress. | 7 |
| 37122003 | 2023 | Activation of ACLY by SEC63 deploys metabolic reprogramming to facilitate hepatocellular carcinoma metastasis upon endoplasmic reticulum stress. | 7 |
| 34429451 | 2021 | Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth. | 8 |
| 34429451 | 2021 | Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth. | 8 |
| 32133789 | 2020 | Identification of signal peptide features for substrate specificity in human Sec62/Sec63-dependent ER protein import. | 22 |
| 33378667 | 2020 | A Molecular Mechanism for Turning Off IRE1α Signaling during Endoplasmic Reticulum Stress. | 25 |
| 32133789 | 2020 | Identification of signal peptide features for substrate specificity in human Sec62/Sec63-dependent ER protein import. | 22 |
| 33378667 | 2020 | A Molecular Mechanism for Turning Off IRE1α Signaling during Endoplasmic Reticulum Stress. | 25 |
| 28973524 | 2017 | Liver cyst gene knockout in cholangiocytes inhibits cilium formation and Wnt signaling. | 2 |
| 28973524 | 2017 | Liver cyst gene knockout in cholangiocytes inhibits cilium formation and Wnt signaling. | 2 |
| 23287549 | 2013 | CK2 phosphorylation of human Sec63 regulates its interaction with Sec62. | 9 |
| 23287549 | 2013 | CK2 phosphorylation of human Sec63 regulates its interaction with Sec62. | 9 |
| 22375059 | 2012 | Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. | 80 |
| 23166619 | 2012 | Role of human sec63 in modulating the steady-state levels of multi-spanning membrane proteins. | 7 |
| 23209713 | 2012 | Loss of heterozygosity is present in SEC63 germline carriers with polycystic liver disease. | 17 |
Citation
Dessen P
SEC63 (SEC63 homolog, protein translocation regulator)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/42242/sec63-(sec63-homolog-protein-translocation-regulator)
