SELE (selectin E, endothelial adhesion molecule 1)
2008-05-01 Gregorio Seidita , Giacomo De Leo , Riccardo Alessandro AffiliationDipartimento Biopatologie e Metodologie Biomediche, via divisi, 83 - 90133 Palermo, Italy
DNA/RNA
Note
Member of the Selectin family. ELAM and CD62E, two of the alternative gene names, have continued to be used in the literature for this gene.
Exons are represented by solid blue rectangles and introns by black lines.The drawing is in scale.
Description
This gene can be found on Chromosome 1 at location 167,958,406-167,969,803. The gene is composed of 14 exons, spanning approximately 12 kb of genomic DNA in the telomere-to-centromere orientation on chromosome region 1q22-1q25. The promoter region is not included.
Transcription
NM_000450 3834 bp mRNA. The sequence is supported by several sequences (cDNA clones) and produces, by alternative splicing, 5 different protein isoforms (6 transcripts). The transcripts differ by truncation of the N-terminus, truncation of the C-terminus, presence or absence of an exon.
Pseudogene
None
Proteins
Description
Selectin E precursor is composed of 610 amino acids (66655 Da). Subcellular location: Membrane; Single-pass type I membrane protein. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues (Sushi domains). E-Selectin belongs to the selectin family of proteins. Amino acids: 610; Molecular Weight: 66655 Dalton. The phosphorylation on Tyr-603 (cytoplasmic domain) is required for the E-selectin-dependent ERK1 / ERK2 activation.
Expression
The endothelial leukocyte adhesion molecule-1 is ubiquitously expressed in normal tissues. SELE is expressed at high level in cytokine-stimulated endothelial cells.
Localisation
Single-pass type I membrane protein.
Function
E-Selectin is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis.
Homology
Using pairwise alignment function of ClustalW2, the corresponding sequences from Mus musculus and Rattus norvegicus match with a score of 72 and 73 respectively.
Mutations
Note
Since adhesion molecules such as members of the selectin family participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis, Wenzel et al. (1994) sought DNA polymorphisms in the ELAM1 gene, which appears to be expressed only in activated endothelium. They identified an A-to-C transversion at cDNA nucleotide 561, resulting in an amino acid exchange from serine to arginine at codon 128 (S128R) in the epidermal growth factor-like domain. They found a significantly higher frequency of the mutation in 97 patients aged 50 years or less with angiographically proven severe atherosclerosis (arginine allele frequency, 0.155) compared with an unselected population (arginine allele frequency, 0.088), as well as in 40 patients aged 40 years or less (arginine allele frequency, 0.21). Mutations of the gene may be a risk factor in atherosclerosis. A polymorphism in position 149 is associated with a higher risk of coronary artery disease (CAD). A significantly higher mutation frequency (Arg-149) is observed in patients with angiographically proven severe atherosclerosis compared with an unselected population (Ser-149).Genomewide linkage and candidate gene-based association studies demonstrated that variation in 3 genes on 1q23 is important in the determination of differences in blood pressure levels: ATP1B1 (182330), RGS5 (603276), and SELE (Takei et al, 2002; 131210). E-selectin S128R polymorphism can functionally affect tumor-endothelial interactions as well as motility and signaling properties of neoplastic cells that may modulate the metastatic phenotype (Alessandro et al, 2007).
Implicated in
Entity name
Recruiting blood leukocytes to the site of inflammation
Note
E-selectin plays an important role in recruiting leukocytes to the site of inflammation. E-selectin is expressed on endothelial cells in response to inflammatory cytokines IL-1 and TNF-alpha (Bevilacqua et al., 1989). Leukocytes in the blood expressing the correct ligand will bind with low affinity to E-selectin, causing the leukocytes to "roll" along the internal surface of the blood vessel as temporary interactions are made and broken. For these reasons the protein encoded by this gene is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining.
Entity name
Coronary artery disease
Note
Risk of acquiring coronary artery disease in patients with type 2 diabetes mellitus increases significantly in the presence of the 128R mutant allele of the E-selectin gene (Abu Amero et al., 2007). Other authors correlated the G98T mutation in the E-selectin gene with a higher risk of premature coronary artery disease (Zheng et al., 2001). Data from other laboratories confirmed the hypothesis that in systemic inflammation altered E-selectin shedding may play a role in arterial damage and implicated this adhesion molecule in atherosclerotic complications in a high-risk condition (Malatino et al., 2007)
Entity name
Colon carcinoma
Note
Transendothelial migration of colon carcinoma cells
Oncogenesis
E-selectin mediates the adhesion of tumor cells to endothelial cells, and this interaction is associated with metastatic dissemination. Alessandro et al.(2007) studied the S128R polymorphism in the E-selectin gene in patients with metastatic colon cancer and its functional significance. Genotyping for S128R polymorphism was performed on 172 cancer patients and on an age-matched control population demonstrated that the R128 allele was more prevalent in the metastatic patients group than in the non metastatic group or normal controls. In vitro, S128R E-selectin transfected Huvec cells, supported increased adhesion as well as increased cellular signalling of T84 cancer cells compared to WT E-selectin and mock transfected Huvec cells. These findings suggest that the E-selectin S128R polymorphism can functionally affect tumor-endothelial interactions as well as motility and signaling properties of neoplastic cells. These interactions may ultimately modulate the metastatic phenotype.
Entity name
Angiogenesis
Note
E-selectin plays an important role in endostatin-mediated antiangiogenesis. E-selectin is required for the antiangiogenic activity of endostatin in vivo and ex vivo, and is sufficient, via a mechanism requiring the E-selectin cytoplasmic domain, to confer endostatin sensitivity in endothelial cells in vitro (Yu et al., 2004).
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 17578587 | 2007 | The interactive role of type 2 diabetes mellitus and E-selectin S128R mutation on susceptibility to coronary heart disease. | Abu-Amero KK et al |
| 7541576 | 1995 | Circulating adhesion molecules during kidney allograft rejection. | Alcalde G et al |
| 17372905 | 2007 | Role of S128R polymorphism of E-selectin in colon metastasis formation. | Alessandro R et al |
| 14984317 | 2004 | Effect of high glucose concentrations on expression of ELAM-1, VCAM-1 and ICAM-1 in HUVEC with and without cytokine activation. | Altannavch TS et al |
| 15083893 | 2004 | E-selectin polymorphism in erythema nodosum secondary to sarcoidosis. | Amoli MM et al |
| 7536194 | 1995 | Modulation of E-selectin structure/function by metal ions. Studies on limited proteolysis and metal ion regeneration. | Anostario M Jr et al |
| 12186696 | 2002 | L and E selectins in acute myeloid leukemia: expression, clinical relevance and relation to patient outcome. | Aref S et al |
| 15784173 | 2005 | Genomic rearrangements on VCAM1, SELE, APEG1and AIF1 loci in atherosclerosis. | Arvanitis DA et al |
| 17452460 | 2007 | HOXA9 participates in the transcriptional activation of E-selectin in endothelial cells. | Bandyopadhyay S et al |
| 2466335 | 1989 | Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. | Bevilacqua MP et al |
| 11935152 | 2002 | Relation between glycaemic control, hyperinsulinaemia and plasma concentrations of soluble adhesion molecules in patients with impaired glucose tolerance or Type II diabetes. | Blüher M et al |
| 12940514 | 2003 | Circulating transforming growth factor-beta1, lipoprotein(a) and cellular adhesion molecules in angiographically assessed coronary artery disease. | Bogavac-Stanojevic N et al |
| 17057786 | 2005 | Analysis of Hemicentin-1, hOgg1, and E-selectin single nucleotide polymorphisms in age-related macular degeneration. | Bojanowski CM et al |
| 15666579 | 2004 | Soluble adhesion molecules are not involved in the development of retinopathy in type 2 diabetic patients. | Boulbou MS et al |
| 11929779 | 2002 | Human mast cell progenitors use alpha4-integrin, VCAM-1, and PSGL-1 E-selectin for adhesive interactions with human vascular endothelium under flow conditions. | Boyce JA et al |
| 12673844 | 2001 | Activation of vascular endothelial cell adhesion molecule expression by sickle blood cells. | Brown MD et al |
| 16565092 | 2006 | HCELL is the major E- and L-selectin ligand expressed on LS174T colon carcinoma cells. | Burdick MM et al |
| 15331359 | 2005 | Flow-conditioned HUVECs support clustered leukocyte adhesion by coexpressing ICAM-1 and E-selectin. | Burns MP et al |
| 14568956 | 2003 | Complement regulatory protein C1 inhibitor binds to selectins and interferes with endothelial-leukocyte adhesion. | Cai S et al |
| 15560890 | 2004 | Extracts from cigarette smoke induce DNA damage and cell adhesion molecule expression through different pathways. | Chen HW et al |
| 10477700 | 1999 | Human immunodeficiency virus-1 (HIV-1)-Tat protein promotes migration of acquired immunodeficiency syndrome-related lymphoma cells and enhances their adhesion to endothelial cells. | Chirivi RG et al |
| 14734737 | 2004 | E-selectin, thymus- and activation-regulated chemokine/CCL17, and intercellular adhesion molecule-1 are constitutively coexpressed in dermal microvessels: a foundation for a cutaneous immunosurveillance system. | Chong BF et al |
| 16963035 | 2006 | Long-term effects of tibolone on circulating levels of vascular cell adhesion molecules and E-selectin in postmenopausal women. | Cicinelli E et al |
| 1703529 | 1991 | Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1. | Collins T et al |
| 11827962 | 2002 | The human immunodeficiency virus-1 Tat protein activates human umbilical vein endothelial cell E-selectin expression via an NF-kappa B-dependent mechanism. | Cota-Gomez A et al |
| 16980970 | 2006 | G-CSF induces E-selectin ligand expression on human myeloid cells. | Dagia NM et al |
| 15009098 | 2004 | Altered tissue expression pattern of cell adhesion molecules, ICAM-1, E-selectin and VCAM-1, in bullous pemphigoid during methotrexate therapy. | Dahlman-Ghozlan K et al |
| 10419878 | 1999 | Loss of endothelial surface expression of E-selectin in a patient with recurrent infections. | DeLisser HM et al |
| 17939599 | 2007 | Ser128Arg E-selectin and Thr715Pro P-selectin polymorphisms and severe preeclampsia. | Derzbach L et al |
| 9269771 | 1997 | Human immunodeficiency virus-1-tat protein induces the cell surface expression of endothelial leukocyte adhesion molecule-1, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 in human endothelial cells. | Dhawan S et al |
| 15593054 | 2004 | Circulating levels of soluble adhesion molecules in patients with ANCA-associated vasculitis. | Di Lorenzo G et al |
| 11402070 | 2001 | CD44 is a major E-selectin ligand on human hematopoietic progenitor cells. | Dimitroff CJ et al |
| 11764211 | 2001 | Association of the A561C E-selectin polymorphism with systemic lupus erythematosus in 2 independent populations. | El-Magadmi M et al |
| 12698264 | 2003 | Enhanced expression of E-selectin on the vascular endothelium of peripheral nerve in critically ill patients with neuromuscular disorders. | Fenzi F et al |
| 12820726 | 2001 | Tumor cell MUC1 and CD43 are glycosylated differently with sialyl-Lewis a and x epitopes and show variable interactions with E-selectin under physiological flow conditions. | Fernandez-Rodriguez J et al |
| 11776680 | 2001 | Localization and quantification of adhesion molecule expression in the lower uterine segment during premature labor. | Fischer DC et al |
| 16269612 | 2006 | CD43 is a ligand for E-selectin on CLA+ human T cells. | Fuhlbrigge RC et al |
| 12738381 | 2003 | Interactions of the gastrotropic bacterium Helicobacter pylori with the leukocyte-endothelium adhesion molecules, the selectins--a preliminary report. | Galustian C et al |
| 15179350 | 2004 | Ser128Arg gene polymorphism for E-selectin and severity of atherosclerotic arterial disease. | Ghilardi G et al |
| 9128259 | 1997 | Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin. | Goetz DJ et al |
| 16501492 | 2006 | Hepatocyte growth factor suppresses acute renal inflammation by inhibition of endothelial E-selectin. | Gong R et al |
| 7509040 | 1994 | Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains. | Graves BJ et al |
| 15187162 | 2004 | Shear-dependent capping of L-selectin and P-selectin glycoprotein ligand 1 by E-selectin signals activation of high-avidity beta2-integrin on neutrophils. | Green CE et al |
| 16710414 | 2006 | The DNA sequence and biological annotation of human chromosome 1. | Gregory SG et al |
| 14534081 | 2004 | Stimulation of adhesion molecule expression in human endothelial cells (HUVEC) by adrenomedullin and corticotrophin. | Hagi-Pavli E et al |
| 12086338 | 2002 | Expression of ICAM-1, VCAM-1, E-selectin and TNF-alpha on the endothelium of femoral and iliac arteries in thromboangiitis obliterans. | Halacheva K et al |
| 10391210 | 1999 | Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. | Halushka MK et al |
| 15735663 | 2005 | A functional interaction between ATF7 and TAF12 that is modulated by TAF4. | Hamard PJ et al |
| 16843446 | 2006 | A561C polymorphism of E-selectin is associated with ischemic cerebrovascular disease in the Japanese population without diabetes mellitus and hypercholesterolemia. | Hattori H et al |
| 1689848 | 1990 | Endothelial leukocyte adhesion molecule 1: direct expression cloning and functional interactions. | Hession C et al |
| 12020443 | 2002 | Mononuclear cell adhesion and cell adhesion molecule liberation after X-irradiation of activated endothelial cells in vitro. | Hildebrandt G et al |
| 7523444 | 1994 | Exogenous tat protein activates central nervous system-derived endothelial cells. | Hofman FM et al |
| 7693046 | 1993 | Exogenous tat protein activates human endothelial cells. | Hofman FM et al |
| 11602579 | 2001 | Molecular events in transmembrane signaling via E-selectin. SHP2 association, adaptor protein complex formation and ERK1/2 activation. | Hu Y et al |
| 15299021 | 2004 | Quantifying the effects of molecular orientation and length on two-dimensional receptor-ligand binding kinetics. | Huang J et al |
| 15167972 | 2004 | An immunoglobulin agent (IVIG) inhibits NF-kappaB activation in cultured endothelial cells of coronary arteries in vitro. | Ichiyama T et al |
| 16908800 | 2006 | Homozygosity in the single nucleotide polymorphism Ser128Arg in the E-selectin gene associated with recurrent venous thromboembolism. | Jilma B et al |
| 12165498 | 2002 | L-selectin serves as an E-selectin ligand on cultured human T lymphoblasts. | Jutila MA et al |
| 11697721 | 2001 | Day-night variations in blood levels of nitric oxide, T-TFPI, and E-selectin. | Kanabrocki EL et al |
| 16916660 | 2006 | Polymorphism in L-selectin, E-selectin and ICAM-1 genes in Asian Indian pediatric patients with celiac disease. | Kaur G et al |
| 16773720 | 2006 | Expression of E-selectin, integrin beta1 and immunoglobulin superfamily member in human gastric carcinoma cells and its clinicopathologic significance. | Ke JJ et al |
| 12960351 | 2003 | Lipid raft localization of cell surface E-selectin is required for ligation-induced activation of phospholipase C gamma. | Kiely JM et al |
| 12200386 | 2002 | Hydrocortisone reduced in vivo, inflammation-induced slow rolling of leukocytes and their extravasation into human conjunctiva. | Kirveskari J et al |
| 17963163 | 2007 | Soluble cell adhesion molecules (sICAM-1, sVCAM-1, and sE-selectin) in patients with early rheumatoid arthritis. | Klimiuk PA et al |
| 11859093 | 2002 | Cutting Edge: Internalization of transduced E-selectin by cultured human endothelial cells: comparison of dermal microvascular and umbilical vein cells and identification of a phosphoserine-type di-leucine motif. | Kluger MS et al |
| 12388172 | 2003 | E-selectin-inducing activity in plasma from type 2 diabetic patients with maculopathy. | Knudsen ST et al |
| 17143564 | 2007 | Periprocedural soluble P- and E-selectin levels fail as predictors of clinical restenosis in patients treated with elective coronary stenting. | Kozinski M et al |
| 12522014 | 2003 | Src and phosphatidylinositol 3-kinase mediate soluble E-selectin-induced angiogenesis. | Kumar P et al |
| 15387376 | 2004 | Adhesion of HT-29 colon carcinoma cells to endothelial cells requires sequential events involving E-selectin and integrin beta4. | Laferrière J et al |
| 15917220 | 2005 | FBI-1 enhances transcription of the nuclear factor-kappaB (NF-kappaB)-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB. | Lee DK et al |
| 15194470 | 2004 | Estrogen-mediated protection against HIV Tat protein-induced inflammatory pathways in human vascular endothelial cells. | Lee YW et al |
| 8621728 | 1996 | Post-translational modifications of recombinant P-selectin glycoprotein ligand-1 required for binding to P- and E-selectin. | Li F et al |
| 16061120 | 2005 | Association between the Ser128Arg variant of the E-selectin and risk of coronary artery disease in the central China. | Li Y et al |
| 12898464 | 2003 | Relationship between circulating E-selectin, DD genotype of angiotensin-converting-enzyme, and cardiovascular damage in central obese subjects. | Licata G et al |
| 12172576 | 2002 | Down regulation of endothelial adhesion molecules in node positive breast cancer: possible failure of host defence mechanism. | Madhavan M et al |
| 17875185 | 2007 | Circulating E-selectin as a risk marker in patients with end-stage renal disease. | Malatino LS et al |
| 12172318 | 2002 | Soluble cell adhesion molecules in hypertensive concentric left ventricular hypertrophy. | Malmqvist K et al |
| 12499405 | 2002 | An investigation of the interactions of E-selectin with fuco-oligosaccharides of the blood group family. | Martín MJ et al |
| 15076188 | 2004 | The Leu554Phe polymorphism in the E-selectin gene is associated with blood pressure in overweight people. | Marteau JB et al |
| 11882338 | 2002 | Serum levels of adhesion molecules correlate with insulin resistance. | Matsumoto K et al |
| 12788528 | 2003 | Different mechanisms of adhesion molecule expression in human dermal microvascular endothelial cells by xanthoma tissue-mediated and copper-mediated oxidized low density lipoproteins. | Matsumoto M et al |
| 15833936 | 2005 | E-selectin genotypes and risk of type 2 diabetes in women. | Meigs JB et al |
| 15080580 | 2004 | Expression of endothelial protein C receptor and thrombomodulin in human coronary atherosclerotic plaques. | Merlini PA et al |
| 7681016 | 1993 | Modelling the carbohydrate recognition domain of human E-selectin. | Mills A et al |
| 9597096 | 1997 | HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium. | Mrowiec T et al |
| 14988223 | 2004 | Ionizing radiation-induced E-selectin gene expression and tumor cell adhesion is inhibited by lovastatin and all-trans retinoic acid. | Nübel T et al |
| 15086468 | 2004 | Endothelial adhesion molecules in glomerular lesions: association with their severity and diversity in lupus models. | Nakatani K et al |
| 17014013 | 2006 | sE-Selectin expression and A561C polymorphism in relation to rheumatoid arthritis clinical activity. | Navarro-Hernández RE et al |
| 7538217 | 1995 | Effects of modified low density lipoprotein and hypoxia on the expression of endothelial leukocyte adhesion molecule-1. | Okada M et al |
| 1701274 | 1990 | ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex. | Phillips ML et al |
| 15304054 | 2004 | Intermittent high glucose enhances ICAM-1, VCAM-1, E-selectin and interleukin-6 expression in human umbilical endothelial cells in culture: the role of poly(ADP-ribose) polymerase. | Piconi L et al |
| 14763917 | 2004 | Body weight and glucose metabolism have a different effect on circulating levels of ICAM-1, E-selectin, and endothelin-1 in humans. | Pontiroli AE et al |
| 11983205 | 2002 | Quantification of the influence of mycophenolic acid on the release of endothelial adhesion molecules. | Raab M et al |
| 17392035 | 2007 | The Ser128Arg polymorphism for E-selectin gene and brucellosis. | Rafiei A et al |
| 12421968 | 2002 | Enhanced recruitment of Th2 and CLA-negative lymphocytes by the S128R polymorphism of E-selectin. | Rao RM et al |
| 11936588 | 2002 | Soluble selectin levels in patients with lung cancer. | Roselli M et al |
| 1375831 | 1992 | Cell-cell contact mechanisms. | Ryan US et al |
| 11847011 | 2002 | Circulating endothelial adhesion molecules (sE-selectin, sVCAM-1 and sICAM-1) during rHuG-CSF-stimulated stem cell mobilization. | Südhoff T et al |
| 10982036 | 2000 | Relationship between E-selectin L/F554 polymorphism and blood pressure in the Stanislas cohort. | Sass C et al |
| 11981814 | 2002 | Contribution of selectin ligands to eosinophil recruitment into the skin of patients with atopic dermatitis. | Satoh T et al |
| 12792758 | 2003 | High serum soluble E-selectin levels are associated with postoperative haematogenic recurrence in esophageal squamous cell carcinoma patients. | Shimada Y et al |
| 17167725 | 2006 | Soluble VCAM-1 and E-selectin in breast cancer: relationship with staging and with the detection of circulating cancer cells. | Silva HC et al |
| 17389327 | 2007 | Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women. | Song Y et al |
| 7694691 | 1993 | Divergent fates of P- and E-selectins after their expression on the plasma membrane. | Subramaniam M et al |
| 12626663 | 2003 | AGI-1067: a multifunctional phenolic antioxidant, lipid modulator, anti-inflammatory and antiatherosclerotic agent. | Sundell CL et al |
| 16892455 | 2007 | Human soluble E-selectin immunoadhesin inhibits leukemic monocyte adhesion to endothelial cells. | Sung BH et al |
| 17684030 | 2007 | A cholesterol-independent membrane microdomain serves as a functional counter-receptor for E-selectin at the Colo201 cell surface and initiates signalling on E-selectin binding. | Suzuki C et al |
| 11828340 | 2002 | Association between single-nucleotide polymorphisms in selectin genes and immunoglobulin A nephropathy. | Takei T et al |
| 14714557 | 2003 | Increased E-selectin, IL-8 and IL-10 gene expression in human skin after minimal trauma. | Takeuchi F et al |
| 9920928 | 1999 | E-selectin gene expression is induced synergistically with the coexistence of activated classic protein kinase C and signals elicited by interleukin-1beta but not tumor necrosis factor-alpha. | Tamaru M et al |
| 15736116 | 2005 | Soluble E-selectin, leptin, triglycerides, and insulin resistance in nonobese Japanese type 2 diabetic patients. | Taniguchi A et al |
| 15488708 | 2004 | In vivo evidence for close association of CLA expression and E-selectin binding by T cells in the inflamed skin. | Teraki Y et al |
| 16554320 | 2006 | The E-selectin gene polymorphism and carotid atherosclerosis in end-stage renal disease. | Testa A et al |
| 16433632 | 2006 | Src-family kinases mediate an outside-in signal necessary for beta2 integrins to achieve full activation and sustain firm adhesion of polymorphonuclear leucocytes tethered on E-selectin. | Totani L et al |
| 11948013 | 2002 | 17beta-Estradiol inhibits cytokine induction of the human E-selectin promoter. | Tyree CM et al |
| 15254658 | 2004 | Serum levels of soluble E-selectin in colorectal cancer. | Uner A et al |
| 17956423 | 2007 | A novel leptospiral protein increases ICAM-1 and E-selectin expression in human umbilical vein endothelial cells. | Vieira ML et al |
| 17142773 | 2006 | Thiocyanate-dependent induction of endothelial cell adhesion molecule expression by phagocyte peroxidases: a novel HOSCN-specific oxidant mechanism to amplify inflammation. | Wang JG et al |
| 16974056 | 2006 | Impact of selectin gene polymorphisms on rapid progression to end-stage renal disease in patients with IgA nephropathy. | Watanabe Y et al |
| 1694218 | 1990 | Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1. | Watson ML et al |
| 8557254 | 1996 | DNA polymorphisms in adhesion molecule genes--a new risk factor for early atherosclerosis. | Wenzel K et al |
| 7533025 | 1994 | E-selectin polymorphism and atherosclerosis: an association study. | Wenzel K et al |
| 11882337 | 2002 | Humoral markers of inflammation and endothelial dysfunction in relation to adiposity and in vivo insulin action in Pima Indians. | Weyer C et al |
| 11404363 | 2001 | Affinity, kinetics, and thermodynamics of E-selectin binding to E-selectin ligand-1. | Wild MK et al |
| 14592840 | 2004 | Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells independent of PSGL-1. | Winkler IG et al |
| 12011765 | 2002 | Blood serum levels of soluble forms of adhesion molecules ICAM-1 (sICAM-1) and selectin E (s-selectin E) in patients with various phases of non-Hodgkin's lymphomas. | Wołowiec D et al |
| 9933738 | 1999 | A PstI polymorphism detects the mutation of serine128 to arginine in CD 62E gene - a risk factor for coronary artery disease. | Ye SQ et al |
| 15515123 | 2005 | Serum E-selectin and erythrocyte membrane Na+K+ ATPase levels in patients with rheumatoid arthritis. | Yildirim K et al |
| 12649084 | 2003 | E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under flow conditions. | Yoshida M et al |
| 8609175 | 1996 | Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton. | Yoshida M et al |
| 15148373 | 2004 | E-selectin is required for the antiangiogenic activity of endostatin. | Yu Y et al |
| 9024699 | 1997 | L-selectin from human, but not from mouse neutrophils binds directly to E-selectin. | Zöllner O et al |
| 14607629 | 2002 | E-selectin and its ligand-sLeX in the metastasis of hepatocellular carcinoma. | Zhang BH et al |
| 14592723 | 2003 | L-selectin and E-selectin expressed on monocytes mediating Ehrlichia chaffeensis attachment onto host cells. | Zhang JZ et al |
| 11168027 | 2001 | An HphI polymorphism in the E-selectin gene is associated with premature coronary artery disease. | Zheng F et al |
Other Information
Locus ID:
NCBI: 6401
MIM: 131210
HGNC: 10718
Ensembl: ENSG00000007908
Variants:
dbSNP: 6401
ClinVar: 6401
TCGA: ENSG00000007908
COSMIC: SELE
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128406956 | fluorouracil | Chemical | ClinicalAnnotation | associated | PD | 24980946 | |
| PA131285527 | oxaliplatin | Chemical | ClinicalAnnotation | associated | PD | 24980946 | |
| PA443756 | Colonic Neoplasms | Disease | ClinicalAnnotation | associated | PD | 24980946 | |
| PA448771 | capecitabine | Chemical | ClinicalAnnotation | associated | PD | 24980946 | |
| PA450198 | leucovorin | Chemical | ClinicalAnnotation | associated | PD | 24980946 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38243063 | 2024 | PSGL-1 decorated with sialyl Lewis(a/x) promotes high affinity binding of myeloma cells to P-selectin but is dispensable for E-selectin engagement. | 0 |
| 38428409 | 2024 | PDGFRα(+)ITGA11(+) fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay. | 4 |
| 38493006 | 2024 | Targeting hematologic malignancies by inhibiting E-selectin: A sweet spot for AML therapy? | 1 |
| 38650162 | 2024 | E-selectin is associated with stable angina and myocardial infarction in a sample of Kurdish population. | 0 |
| 38243063 | 2024 | PSGL-1 decorated with sialyl Lewis(a/x) promotes high affinity binding of myeloma cells to P-selectin but is dispensable for E-selectin engagement. | 0 |
| 38428409 | 2024 | PDGFRα(+)ITGA11(+) fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay. | 4 |
| 38493006 | 2024 | Targeting hematologic malignancies by inhibiting E-selectin: A sweet spot for AML therapy? | 1 |
| 38650162 | 2024 | E-selectin is associated with stable angina and myocardial infarction in a sample of Kurdish population. | 0 |
| 33022186 | 2023 | Association of E-Selectin gene polymorphisms and serum E-Selectin level with risk of coronary artery disease in lur population of Iran. | 4 |
| 35982357 | 2023 | Increased Circulating CD62E(+) Endothelial Extracellular Vesicles Predict Severity and in- Hospital Mortality of COVID-19 Patients. | 7 |
| 36409296 | 2023 | Plasma levels of E-selectin are associated with retinopathy in sickle cell disease. | 2 |
| 37903858 | 2023 | E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation. | 5 |
| 33022186 | 2023 | Association of E-Selectin gene polymorphisms and serum E-Selectin level with risk of coronary artery disease in lur population of Iran. | 4 |
| 35982357 | 2023 | Increased Circulating CD62E(+) Endothelial Extracellular Vesicles Predict Severity and in- Hospital Mortality of COVID-19 Patients. | 7 |
| 36409296 | 2023 | Plasma levels of E-selectin are associated with retinopathy in sickle cell disease. | 2 |
Citation
Gregorio Seidita ; Giacomo De Leo ; Riccardo Alessandro
SELE (selectin E, endothelial adhesion molecule 1)
Atlas Genet Cytogenet Oncol Haematol. 2008-05-01
Online version: http://atlasgeneticsoncology.org/gene/42247/sele-%28selectin-e-endothelial-adhesion-molecule-1%29
