SELL (selectin L)

2003-08-01  

Identity

HGNC
LOCATION
1q24.2
LOCUSID
ALIAS
CD62L,LAM1,LECAM1,LEU8,LNHR,LSEL,LYAM1,PLNHR,TQ1
FUSION GENES

Other Information

Locus ID:

NCBI: 6402
MIM: 153240
HGNC: 10720
Ensembl: ENSG00000188404

Variants:

dbSNP: 6402
ClinVar: 6402
TCGA: ENSG00000188404
COSMIC: SELL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188404ENST00000236147P14151
ENSG00000188404ENST00000497295A0A494C0S7
ENSG00000188404ENST00000650983P14151

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
234870232013NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17).124
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
187139682008FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase.97
125320212003Trophoblast L-selectin-mediated adhesion at the maternal-fetal interface.89
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
183753922008Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow.66
118214312002Oversulfated chondroitin/dermatan sulfates containing GlcAbeta1/IdoAalpha1-3GalNAc(4,6-O-disulfate) interact with L- and P-selectin and chemokines.57
163526502006Variant isoforms of CD44 are P- and L-selectin ligands on colon carcinoma cells.52
178903992008Monitoring receptor-ligand interactions between surfaces by thermal fluctuations.51
165650922006HCELL is the major E- and L-selectin ligand expressed on LS174T colon carcinoma cells.46

Citation

Dessen P

SELL (selectin L)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42249/sell-(selectin-l)