SEMA5A (semaphorin 5A)

2003-11-01  

Identity

HGNC
LOCATION
5p15.31
LOCUSID
ALIAS
SEMAF,semF
FUSION GENES

Other Information

Locus ID:

NCBI: 9037
MIM: 609297
HGNC: 10736
Ensembl: ENSG00000112902

Variants:

dbSNP: 9037
ClinVar: 9037
TCGA: ENSG00000112902
COSMIC: SEMA5A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112902ENST00000382496Q13591
ENSG00000112902ENST00000382496X5DR95
ENSG00000112902ENST00000513968D6RAF4
ENSG00000112902ENST00000652226Q13591
ENSG00000112902ENST00000652226X5DR95

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-glycosylation of TSR domain-containing proteinsREACTOMER-HSA-5173214
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
Other semaphorin interactionsREACTOMER-HSA-416700
Diseases associated with O-glycosylation of proteinsREACTOMER-HSA-3906995
Defective B3GALTL causes Peters-plus syndrome (PpS)REACTOMER-HSA-5083635

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
367412302023SEMA5A-PLXNB3 Axis Promotes PDAC Liver Metastasis Outgrowth through Enhancing the Warburg Effect.3
371645462023Circular RNA circSEMA5A facilitates colorectal cancer development by regulating microRNA-195-5p to target CCNE1 axis.1
367412302023SEMA5A-PLXNB3 Axis Promotes PDAC Liver Metastasis Outgrowth through Enhancing the Warburg Effect.3
371645462023Circular RNA circSEMA5A facilitates colorectal cancer development by regulating microRNA-195-5p to target CCNE1 axis.1
358357482022Semaphorin 5A suppresses ferroptosis through activation of PI3K-AKT-mTOR signaling in rheumatoid arthritis.22
358357482022Semaphorin 5A suppresses ferroptosis through activation of PI3K-AKT-mTOR signaling in rheumatoid arthritis.22
336166192021TSP1 is the essential domain of SEMA5A involved in pannus formation in rheumatoid arthritis.5
337710902021Relationship between disease and disease severity and semaphorin 5A and hemogram level in obsessive-compulsive disorder.1
338012962021The Expression of IL-17, in Chronic Spontaneous Urticaria Is Linked to Semaphorin5A.1
336166192021TSP1 is the essential domain of SEMA5A involved in pannus formation in rheumatoid arthritis.5
337710902021Relationship between disease and disease severity and semaphorin 5A and hemogram level in obsessive-compulsive disorder.1
338012962021The Expression of IL-17, in Chronic Spontaneous Urticaria Is Linked to Semaphorin5A.1
315447152020Assessment of the Usefulness of the SEMA5A Concentration Profile Changes as a Molecular Marker in Endometrial Cancer.3
315971582020High Expression Levels of Long Noncoding RNA Small Nucleolar RNA Host Gene 18 and Semaphorin 5A Indicate Poor Prognosis in Multiple Myeloma.11
317893972020Semaphorin 5A suppresses the proliferation and migration of lung adenocarcinoma cells.6

Citation

Dessen P

SEMA5A (semaphorin 5A)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42257/sema5a-(semaphorin-5a)