SENP6 (SUMO specific peptidase 6)

2003-02-01  

Identity

HGNC
LOCATION
6q14.1
LOCUSID
ALIAS
SSP1,SUSP1
FUSION GENES

Other Information

Locus ID:

NCBI: 26054
MIM: 605003
HGNC: 20944
Ensembl: ENSG00000112701

Variants:

dbSNP: 26054
ClinVar: 26054
TCGA: ENSG00000112701
COSMIC: SENP6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112701ENST00000327284F8W6D9
ENSG00000112701ENST00000370010Q9GZR1
ENSG00000112701ENST00000424947H0Y4F4
ENSG00000112701ENST00000447266Q9GZR1
ENSG00000112701ENST00000483859D6RG09
ENSG00000112701ENST00000493959D6RJH1
ENSG00000112701ENST00000503501H0Y8Y8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
145638522004Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1.71
170008752006SUSP1 antagonizes formation of highly SUMO2/3-conjugated species.59
187994552008Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7.51
202123172010The SUMO protease SENP6 is essential for inner kinetochore assembly.48
169120442006Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1.26
211482992011The SUMO protease SENP6 is a direct regulator of PML nuclear bodies.19
218786242011Swapping small ubiquitin-like modifier (SUMO) isoform specificity of SUMO proteases SENP6 and SENP7.10
244246312014Structural insights into the SENP6 Loop1 structure in complex with SUMO2.5
286152012017The Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Inhibits Expression of SUMO/Sentrin-Specific Peptidase 6 To Facilitate Establishment of Latency.4
314850032019The poly-SUMO2/3 protease SENP6 enables assembly of the constitutive centromere-associated network by group deSUMOylation.4

Citation

Dessen P

SENP6 (SUMO specific peptidase 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42259/senp6-(sumo-specific-peptidase-6)