Identity
HGNC
LOCATION
14q32.13
LOCUSID
ALIAS
AACT,ACT,GIG24,GIG25
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 12
MIM: 107280
HGNC: 16
Ensembl: ENSG00000196136
Variants:
dbSNP: 12
ClinVar: 12
TCGA: ENSG00000196136
COSMIC: SERPINA3
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA445218 | Pancreatic Neoplasms | Disease | ClinicalAnnotation | associated | PD | 21487324 | |
| PA452621 | antineoplastic agents | Chemical | ClinicalAnnotation | associated | PD | 21487324 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37454278 | 2024 | LAMB3 Promotes Intestinal Inflammation Through SERPINA3 and Is Directly Transcriptionally Regulated by P65 in Inflammatory Bowel Disease. | 1 |
| 37721405 | 2024 | SERPINA3: A novel inflammatory biomarker associated with cerebral small vessel disease burden in ischemic stroke. | 4 |
| 38133876 | 2024 | Hypothermic machine perfusion reduces donation after circulatory death liver ischemia-reperfusion injury through the SERPINA3-mediated PI3Kδ/Akt pathway. | 0 |
| 38647003 | 2024 | Regulation of CNS pathology by Serpina3n/SERPINA3: The knowns and the puzzles. | 1 |
| 37454278 | 2024 | LAMB3 Promotes Intestinal Inflammation Through SERPINA3 and Is Directly Transcriptionally Regulated by P65 in Inflammatory Bowel Disease. | 1 |
| 37721405 | 2024 | SERPINA3: A novel inflammatory biomarker associated with cerebral small vessel disease burden in ischemic stroke. | 4 |
| 38133876 | 2024 | Hypothermic machine perfusion reduces donation after circulatory death liver ischemia-reperfusion injury through the SERPINA3-mediated PI3Kδ/Akt pathway. | 0 |
| 38647003 | 2024 | Regulation of CNS pathology by Serpina3n/SERPINA3: The knowns and the puzzles. | 1 |
| 35007692 | 2023 | Association of α-1-Antichymotrypsin Expression with the Development of Conformational Changes of Tau Protein in Alzheimer's Disease Brain. | 1 |
| 36828876 | 2023 | Newly revealed variants of SERPINA3 in generalized pustular psoriasis attenuate inhibition of ACT on cathepsin G. | 1 |
| 37417362 | 2023 | Overexpression of SERPINA3 suppresses tumor progression by modulating SPOP/NF‑κB in lung cancer. | 0 |
| 35007692 | 2023 | Association of α-1-Antichymotrypsin Expression with the Development of Conformational Changes of Tau Protein in Alzheimer's Disease Brain. | 1 |
| 36828876 | 2023 | Newly revealed variants of SERPINA3 in generalized pustular psoriasis attenuate inhibition of ACT on cathepsin G. | 1 |
| 37417362 | 2023 | Overexpression of SERPINA3 suppresses tumor progression by modulating SPOP/NF‑κB in lung cancer. | 0 |
| 35416570 | 2022 | Serpin Signatures in Prion and Alzheimer's Diseases. | 18 |
Citation
Dessen P
SERPINA3 (serpin family A member 3)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/42263/serpina3-(serpin-family-a-member-3)
