Identity
HGNC
LOCATION
18q21.33
LOCUSID
ALIAS
HsT1201,PAI,PAI-2,PAI2,PLANH2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5055
MIM: 173390
HGNC: 8584
Ensembl: ENSG00000197632
Variants:
dbSNP: 5055
ClinVar: 5055
TCGA: ENSG00000197632
COSMIC: SERPINB2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Complement and coagulation cascades | KEGG | ko04610 |
| Complement and coagulation cascades | KEGG | hsa04610 |
| Hemostasis | REACTOME | R-HSA-109582 |
| Dissolution of Fibrin Clot | REACTOME | R-HSA-75205 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36251494 | 2024 | miR-450b promotes cell migration and invasion by inhibiting SERPINB2 in oral squamous cell carcinoma. | 1 |
| 38741146 | 2024 | Estetrol/GPER/SERPINB2 transduction signaling inhibits the motility of triple-negative breast cancer cells. | 0 |
| 36251494 | 2024 | miR-450b promotes cell migration and invasion by inhibiting SERPINB2 in oral squamous cell carcinoma. | 1 |
| 38741146 | 2024 | Estetrol/GPER/SERPINB2 transduction signaling inhibits the motility of triple-negative breast cancer cells. | 0 |
| 35406715 | 2022 | A Novel Role for Plasminogen Activator Inhibitor Type-2 as a Hypochlorite-Resistant Serine Protease Inhibitor and Holdase Chaperone. | 5 |
| 35466366 | 2022 | Unveiling a novel serpinB2-tripeptidyl peptidase II signaling axis during senescence. | 0 |
| 36497110 | 2022 | SERPINB2, an Early Responsive Gene to Epigallocatechin Gallate, Inhibits Migration and Promotes Apoptosis in Esophageal Cancer Cells. | 1 |
| 35406715 | 2022 | A Novel Role for Plasminogen Activator Inhibitor Type-2 as a Hypochlorite-Resistant Serine Protease Inhibitor and Holdase Chaperone. | 5 |
| 35466366 | 2022 | Unveiling a novel serpinB2-tripeptidyl peptidase II signaling axis during senescence. | 0 |
| 36497110 | 2022 | SERPINB2, an Early Responsive Gene to Epigallocatechin Gallate, Inhibits Migration and Promotes Apoptosis in Esophageal Cancer Cells. | 1 |
| 32404981 | 2021 | HKB99, an allosteric inhibitor of phosphoglycerate mutase 1, suppresses invasive pseudopodia formation and upregulates plasminogen activator inhibitor-2 in erlotinib-resistant non-small cell lung cancer cells. | 7 |
| 33227315 | 2021 | Plasminogen activator Inhibitor-2 inhibits pulmonary arterial smooth muscle cell proliferation in pulmonary arterial hypertension via PI3K/Akt and ERK signaling. | 7 |
| 33387293 | 2021 | SERPINB2-its regulation and interplay with aryl hydrocarbon receptor. | 6 |
| 34095322 | 2021 | HMSC-Derived Exosome Inhibited Th2 Cell Differentiation via Regulating miR-146a-5p/SERPINB2 Pathway. | 16 |
| 32404981 | 2021 | HKB99, an allosteric inhibitor of phosphoglycerate mutase 1, suppresses invasive pseudopodia formation and upregulates plasminogen activator inhibitor-2 in erlotinib-resistant non-small cell lung cancer cells. | 7 |
Citation
Dessen P
SERPINB2 (serpin family B member 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/42264/serpinb2-(serpin-family-b-member-2)
