SETDB1 (SET domain bifurcated histone lysine methyltransferase 1)

2003-02-01  

Identity

HGNC
SETDB1
LOCATION
1q21.3
LOCUSID
9869
ALIAS
ESET,H3-K9-HMTase4,KG1T,KMT1E,TDRD21
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9869
MIM: 604396
HGNC: 10761
Ensembl: ENSG00000143379

Variants:

dbSNP: 9869
ClinVar: 9869
TCGA: ENSG00000143379
COSMIC: SETDB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143379ENST00000271640Q15047
ENSG00000143379ENST00000368962Q15047
ENSG00000143379ENST00000368963X6R732
ENSG00000143379ENST00000368964E9PAP1
ENSG00000143379ENST00000368969Q15047
ENSG00000143379ENST00000423081X6RHV1
ENSG00000143379ENST00000448029B0QZE6
ENSG00000143379ENST00000498193E9PRF4
ENSG00000143379ENST00000525956E9PS59
ENSG00000143379ENST00000534805E9PQM8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Lysine degradationKEGGko00310
Lysine degradationKEGGhsa00310
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
PKMTs methylate histone lysinesREACTOMER-HSA-3214841

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381595742024Structural evidence for protein-protein interaction between the non-canonical methyl-CpG-binding domain of SETDB proteins and C11orf46.0
383172002024SETDB1 promotes progression through upregulation of SF3B4 expression and regulates the immunity in ovarian cancer.0
384265792024Cytoplasmic localization of SETDB1‑induced Warburg effect via c‑MYC‑LDHA axis enhances migration and invasion in breast carcinoma.0
385830212024[Downregulation of SETDB1 suppresses epithelial mesenchymal transition and invasion and metastasis in oral cancer via SOX7 methylation].0
389048422024SETDB1 deletion causes DNA demethylation and upregulation of multiple zinc-finger genes.0
381595742024Structural evidence for protein-protein interaction between the non-canonical methyl-CpG-binding domain of SETDB proteins and C11orf46.0
383172002024SETDB1 promotes progression through upregulation of SF3B4 expression and regulates the immunity in ovarian cancer.0
384265792024Cytoplasmic localization of SETDB1‑induced Warburg effect via c‑MYC‑LDHA axis enhances migration and invasion in breast carcinoma.0
385830212024[Downregulation of SETDB1 suppresses epithelial mesenchymal transition and invasion and metastasis in oral cancer via SOX7 methylation].0
389048422024SETDB1 deletion causes DNA demethylation and upregulation of multiple zinc-finger genes.0
365244352023SETDB1: A perspective into immune cell function and cancer immunotherapy.2
366374242023SETDB1 Modulates Degradation of Phosphorylated RB and Anticancer Efficacy of CDK4/6 Inhibitors.7
367375332023Epigenetic inhibition of lncRNA GMDS-AS1 by methyltransferase ESET promoted cell viability and metastasis of hepatocellular carcinoma.0
368116552023Histone H3K9 methyltransferase SETDB1 overexpression correlates with pediatric high-grade gliomas progression and prognosis.2
369924192023Pregnancy Is Associated with Impaired Transcription of Human Endogenous Retroviruses and of TRIM28 and SETDB1, Particularly in Mothers Affected by Multiple Sclerosis.1

Citation

Dessen P

SETDB1 (SET domain bifurcated histone lysine methyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42273/setdb1-(set-domain-bifurcated-histone-lysine-methyltransferase-1)