SFRP5 (secreted frizzled related protein 5)

2003-11-01  

Identity

HGNC
LOCATION
10q24.2
LOCUSID
ALIAS
SARP3
FUSION GENES

Other Information

Locus ID:

NCBI: 6425
MIM: 604158
HGNC: 10779
Ensembl: ENSG00000120057

Variants:

dbSNP: 6425
ClinVar: 6425
TCGA: ENSG00000120057
COSMIC: SFRP5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120057ENST00000266066Q5T4F7

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164712563BisphosphonatesChemicalClinicalAnnotationassociatedPD
PA445187OsteonecrosisDiseaseClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
199573352010Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway.56
166090232006Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection.53
183561472008Epigenetic inactivation of the secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis.41
185921562008Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma.37
223842492012Pro-inflammatory wnt5a and anti-inflammatory sFRP5 are differentially regulated by nutritional factors in obese human subjects.35
208116862010WNT pathway in oral cancer: epigenetic inactivation of WNT-inhibitors.33
231850362013Circulating Sfrp5 is a signature of obesity-related metabolic disorders and is regulated by glucose and liraglutide in humans.32
199268682010A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma.31
184979872008Epigenetic inactivation of SFRP genes in oral squamous cell carcinoma.30
207957892010Acute myeloid leukemia is characterized by Wnt pathway inhibitor promoter hypermethylation.26

Citation

Dessen P

SFRP5 (secreted frizzled related protein 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42278/sfrp5-(secreted-frizzled-related-protein-5)