ST6GAL1 (ST6 beta-galactoside alpha-2,6-sialyltransferase 1)

2003-11-01 Affiliation

Identity

HGNC

ST6GAL1

LOCATION

3q27.3

LOCUSID

6480

ALIAS

SIAT1,ST6GalI,ST6N

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6480
MIM: 109675
HGNC: 10860
Ensembl: ENSG00000073849

Variants:

dbSNP: 6480
ClinVar: 6480
TCGA: ENSG00000073849
COSMIC: ST6GAL1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000073849	ENST00000169298	P15907
ENSG00000073849	ENST00000416235	C9JKG0
ENSG00000073849	ENST00000417392	C9K0R8
ENSG00000073849	ENST00000423451	C9J6X5
ENSG00000073849	ENST00000427315	C9JVK7
ENSG00000073849	ENST00000430309	C9JTR0
ENSG00000073849	ENST00000438590	C9JI90
ENSG00000073849	ENST00000440338	C9JPG6
ENSG00000073849	ENST00000442023	C9JH16
ENSG00000073849	ENST00000446170	C9JR47
ENSG00000073849	ENST00000448044	P15907
ENSG00000073849	ENST00000448408	C9JFM4
ENSG00000073849	ENST00000448449	H7C472
ENSG00000073849	ENST00000455441	C9JAT4
ENSG00000073849	ENST00000457772	P15907
ENSG00000073849	ENST00000458216	C9IYS8

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
N-Glycan biosynthesis	KEGG	ko00510
Other types of O-glycan biosynthesis	KEGG	ko00514
N-Glycan biosynthesis	KEGG	hsa00510
Other types of O-glycan biosynthesis	KEGG	hsa00514
Metabolic pathways	KEGG	hsa01100
N-glycan biosynthesis, complex type	KEGG	hsa_M00075
N-glycan biosynthesis, complex type	KEGG	M00075
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Asparagine N-linked glycosylation	REACTOME	R-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	REACTOME	R-HSA-446193
Synthesis of substrates in N-glycan biosythesis	REACTOME	R-HSA-446219
Sialic acid metabolism	REACTOME	R-HSA-4085001
Transport to the Golgi and subsequent modification	REACTOME	R-HSA-948021
N-glycan antennae elongation in the medial/trans-Golgi	REACTOME	R-HSA-975576
N-Glycan antennae elongation	REACTOME	R-HSA-975577
O-linked glycosylation	REACTOME	R-HSA-5173105
O-linked glycosylation of mucins	REACTOME	R-HSA-913709
Termination of O-glycan biosynthesis	REACTOME	R-HSA-977068

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA164781042	flucloxacillin	Chemical	Literature, MultilinkAnnotation	associated			19483685

References

Pubmed ID	Year	Title	Citations
37326830	2024	CCCTC-binding factor: the specific transcription factor of β-galactoside α-2,6-sialyltransferase 1 that upregulates the sialylation of anti-citrullinated protein antibodies in rheumatoid arthritis.	2
38490094	2024	N-linked α2,6-sialylation of integrin β1 by the sialyltransferase ST6Gal1 promotes cell proliferation and stemness in gestational trophoblastic disease.	0
37326830	2024	CCCTC-binding factor: the specific transcription factor of β-galactoside α-2,6-sialyltransferase 1 that upregulates the sialylation of anti-citrullinated protein antibodies in rheumatoid arthritis.	2
38490094	2024	N-linked α2,6-sialylation of integrin β1 by the sialyltransferase ST6Gal1 promotes cell proliferation and stemness in gestational trophoblastic disease.	0
36528750	2023	ST6GAL1 inhibits metastasis of hepatocellular carcinoma via modulating sialylation of MCAM on cell surface.	6
36646912	2023	Role of ST6GAL1 and ST6GAL2 in subversion of cellular signaling during enteroaggregative Escherichia coli infection of human intestinal epithelial cell lines.	2
37364046	2023	Role of the ST6GAL1 sialyltransferase in regulating ovarian cancer cell metabolism.	1
37550801	2023	ST6GAL1-mediated aberrant sialylation promotes prostate cancer progression.	6
37643018	2023	ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression.	3
37660914	2023	Sialylation of EGFR by ST6GAL1 induces receptor activation and modulates trafficking dynamics.	5
38003522	2023	Role of ST6GAL1 in Thyroid Cancers: Insights from Tissue Analysis and Genomic Datasets.	0
36528750	2023	ST6GAL1 inhibits metastasis of hepatocellular carcinoma via modulating sialylation of MCAM on cell surface.	6
36646912	2023	Role of ST6GAL1 and ST6GAL2 in subversion of cellular signaling during enteroaggregative Escherichia coli infection of human intestinal epithelial cell lines.	2
37364046	2023	Role of the ST6GAL1 sialyltransferase in regulating ovarian cancer cell metabolism.	1
37550801	2023	ST6GAL1-mediated aberrant sialylation promotes prostate cancer progression.	6

Citation

Dessen P

ST6GAL1 (ST6 beta-galactoside alpha-2,6-sialyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42295/st6gal1-(st6-beta-galactoside-alpha-2-6-sialyltransferase-1)