Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 27180
MIM: 605640
HGNC: 10878
Ensembl: ENSG00000129450
Variants:
dbSNP: 27180
ClinVar: 27180
TCGA: ENSG00000129450
COSMIC: SIGLEC9
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000129450 | ENST00000250360 | Q9Y336 |
| ENSG00000129450 | ENST00000440804 | Q9Y336 |
| ENSG00000129450 | ENST00000599948 | M0R2D4 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38412768 | 2024 | Expression of Siglec-9 in peripheral blood neutrophils was increased and associated with disease severity in patients with AECOPD. | 1 |
| 38454157 | 2024 | The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis. | 0 |
| 38412768 | 2024 | Expression of Siglec-9 in peripheral blood neutrophils was increased and associated with disease severity in patients with AECOPD. | 1 |
| 38454157 | 2024 | The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis. | 0 |
| 36688997 | 2023 | LINC01004-SPI1 axis-activated SIGLEC9 in tumor-associated macrophages induces radioresistance and the formation of immunosuppressive tumor microenvironment in esophageal squamous cell carcinoma. | 6 |
| 36728420 | 2023 | Siglec-9 Restrains Antibody-Dependent Natural Killer Cell Cytotoxicity against SARS-CoV-2. | 4 |
| 37460871 | 2023 | Siglec-9 acts as an immune-checkpoint molecule on macrophages in glioblastoma, restricting T-cell priming and immunotherapy response. | 16 |
| 37865296 | 2023 | The change of Siglec-9 expression in peripheral blood NK cells of SFTS patients can affect the function of NK cells. | 1 |
| 36688997 | 2023 | LINC01004-SPI1 axis-activated SIGLEC9 in tumor-associated macrophages induces radioresistance and the formation of immunosuppressive tumor microenvironment in esophageal squamous cell carcinoma. | 6 |
| 36728420 | 2023 | Siglec-9 Restrains Antibody-Dependent Natural Killer Cell Cytotoxicity against SARS-CoV-2. | 4 |
| 37460871 | 2023 | Siglec-9 acts as an immune-checkpoint molecule on macrophages in glioblastoma, restricting T-cell priming and immunotherapy response. | 16 |
| 37865296 | 2023 | The change of Siglec-9 expression in peripheral blood NK cells of SFTS patients can affect the function of NK cells. | 1 |
| 35854240 | 2022 | Identification and validation of a siglec-based and aging-related 9-gene signature for predicting prognosis in acute myeloid leukemia patients. | 4 |
| 35854240 | 2022 | Identification and validation of a siglec-based and aging-related 9-gene signature for predicting prognosis in acute myeloid leukemia patients. | 4 |
| 33431669 | 2021 | Modulation of immune cell reactivity with cis-binding Siglec agonists. | 25 |
Citation
Dessen P
SIGLEC9 (sialic acid binding Ig like lectin 9)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/42296/siglec9
