SMARCA2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2)
2003-02-01 AffiliationIdentity
HGNC
LOCATION
9p24.3
LOCUSID
ALIAS
BAF190,BIS,BRM,NCBRS,SNF2,SNF2L2,SNF2LA,SWI2,Sth1p,hBRM,hSNF2a
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6595
MIM: 600014
HGNC: 11098
Ensembl: ENSG00000080503
Variants:
dbSNP: 6595
ClinVar: 6595
TCGA: ENSG00000080503
COSMIC: SMARCA2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Chromatin organization | REACTOME | R-HSA-4839726 |
| Chromatin modifying enzymes | REACTOME | R-HSA-3247509 |
| RMTs methylate histone arginines | REACTOME | R-HSA-3214858 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37634210 | 2023 | Expression of SMARCA2 and SMARCA4 in gastric adenocarcinoma and construction of a nomogram prognostic model. | 1 |
| 37634210 | 2023 | Expression of SMARCA2 and SMARCA4 in gastric adenocarcinoma and construction of a nomogram prognostic model. | 1 |
| 34812766 | 2022 | SWI/SNF Complex-deficient Undifferentiated Carcinoma of the Gastrointestinal Tract: Clinicopathologic Study of 30 Cases With an Emphasis on Variable Morphology, Immune Features, and the Prognostic Significance of Different SMARCA4 and SMARCA2 Subunit Deficiencies. | 10 |
| 35289322 | 2022 | SMARCA2 deficiency in NSCLC: a clinicopathologic and immunohistochemical analysis of a large series from a single institution. | 0 |
| 35811451 | 2022 | Ten-year follow-up of Nicolaides-Baraitser syndrome with a de novo mutation and analysis of 58 gene loci of SMARCA2-associated NCBRS. | 3 |
| 36464671 | 2022 | Clinicopathological and prognostic significance of SWI/SNF complex subunits in undifferentiated gastric carcinoma. | 3 |
| 34812766 | 2022 | SWI/SNF Complex-deficient Undifferentiated Carcinoma of the Gastrointestinal Tract: Clinicopathologic Study of 30 Cases With an Emphasis on Variable Morphology, Immune Features, and the Prognostic Significance of Different SMARCA4 and SMARCA2 Subunit Deficiencies. | 10 |
| 35289322 | 2022 | SMARCA2 deficiency in NSCLC: a clinicopathologic and immunohistochemical analysis of a large series from a single institution. | 0 |
| 35811451 | 2022 | Ten-year follow-up of Nicolaides-Baraitser syndrome with a de novo mutation and analysis of 58 gene loci of SMARCA2-associated NCBRS. | 3 |
| 36464671 | 2022 | Clinicopathological and prognostic significance of SWI/SNF complex subunits in undifferentiated gastric carcinoma. | 3 |
| 33027072 | 2021 | SMARCA4/SMARCA2-deficient Carcinoma of the Esophagus and Gastroesophageal Junction. | 9 |
| 33481850 | 2021 | The clinicopathological significance of SWI/SNF alterations in gastric cancer is associated with the molecular subtypes. | 11 |
| 33602783 | 2021 | SMARCA2 Is a Novel Interactor of NSD2 and Regulates Prometastatic PTP4A3 through Chromatin Remodeling in t(4;14) Multiple Myeloma. | 11 |
| 34289068 | 2021 | The Bromodomains of the mammalian SWI/SNF (mSWI/SNF) ATPases Brahma (BRM) and Brahma Related Gene 1 (BRG1) promote chromatin interaction and are critical for skeletal muscle differentiation. | 12 |
| 34518526 | 2021 | SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca(2+) flux to mitochondria. | 13 |
Citation
Dessen P
SMARCA2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/42331
