Identity
HGNC
LOCATION
7q32.1
LOCUSID
ALIAS
CRJS,FZD11,Gx,PHLS,SMOH
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6608
MIM: 601500
HGNC: 11119
Ensembl: ENSG00000128602
Variants:
dbSNP: 6608
ClinVar: 6608
TCGA: ENSG00000128602
COSMIC: SMO
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000128602 | ENST00000249373 | Q99835 |
| ENSG00000128602 | ENST00000462420 | H7C509 |
| ENSG00000128602 | ENST00000475779 | H7C5S9 |
| ENSG00000128602 | ENST00000655644 | A0A590UJE7 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38181892 | 2024 | HERC4 modulates ovarian cancer cell proliferation by regulating SMO-elicited hedgehog signaling. | 0 |
| 38181892 | 2024 | HERC4 modulates ovarian cancer cell proliferation by regulating SMO-elicited hedgehog signaling. | 0 |
| 37830570 | 2023 | Increasing Ciliary ARL13B Expression Drives Active and Inhibitor-Resistant Smoothened and GLI into Glioma Primary Cilia. | 2 |
| 37830570 | 2023 | Increasing Ciliary ARL13B Expression Drives Active and Inhibitor-Resistant Smoothened and GLI into Glioma Primary Cilia. | 2 |
| 33206287 | 2022 | Understanding Abnormal SMO-SHH Signaling in Autism Spectrum Disorder: Potential Drug Target and Therapeutic Goals. | 12 |
| 34893758 | 2022 | Smoothened (SMO) regulates insulin-like growth factor 1 receptor (IGF1R) levels and protein kinase B (AKT) localization and signaling. | 5 |
| 34994576 | 2022 | Genetic Study of BRAF V600E and SMO L412F Mutations in Japanese Patients with Ameloblastoma. | 3 |
| 35152650 | 2022 | [Detection of SMO gene mutations in odontogenic keratocyst]. | 1 |
| 33206287 | 2022 | Understanding Abnormal SMO-SHH Signaling in Autism Spectrum Disorder: Potential Drug Target and Therapeutic Goals. | 12 |
| 34893758 | 2022 | Smoothened (SMO) regulates insulin-like growth factor 1 receptor (IGF1R) levels and protein kinase B (AKT) localization and signaling. | 5 |
| 34994576 | 2022 | Genetic Study of BRAF V600E and SMO L412F Mutations in Japanese Patients with Ameloblastoma. | 3 |
| 35152650 | 2022 | [Detection of SMO gene mutations in odontogenic keratocyst]. | 1 |
| 33348053 | 2021 | sEVs from tonsil-derived mesenchymal stromal cells alleviate activation of hepatic stellate cells and liver fibrosis through miR-486-5p. | 24 |
| 33398379 | 2021 | Silencing of long non‑coding RNA NEAT1 inhibits hepatocellular carcinoma progression by downregulating SMO by sponging microRNA‑503. | 4 |
| 33446260 | 2021 | A novel protein encoded by circular SMO RNA is essential for Hedgehog signaling activation and glioblastoma tumorigenicity. | 74 |
Citation
Dessen P
SMO (smoothened, frizzled class receptor)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/42340
