SNX6 (sorting nexin 6)

2003-06-01  

Identity

HGNC
SNX6
LOCATION
14q13.1
LOCUSID
58533
ALIAS
MSTP010,TFAF2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 58533
MIM: 606098
HGNC: 14970
Ensembl: ENSG00000129515

Variants:

dbSNP: 58533
ClinVar: 58533
TCGA: ENSG00000129515
COSMIC: SNX6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129515ENST00000362031Q9UNH7
ENSG00000129515ENST00000396526Q9UNH7
ENSG00000129515ENST00000555416G3V4Z5
ENSG00000129515ENST00000555648G3V5U2
ENSG00000129515ENST00000556162G3V589
ENSG00000129515ENST00000556712H0YJF8
ENSG00000129515ENST00000557265G3V5X9
ENSG00000129515ENST00000557341G3V2U1
ENSG00000129515ENST00000652385A0A0A0MRI2

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
171485742007A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer.88
199357742009The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport.40
203541422010Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing.38
208307432010Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression.5
315760582019Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins.4
303074732018SNX6 predicts poor prognosis and contributes to the metastasis of pancreatic cancer cells via activating epithelial-mesenchymal transition.3
295309812018The proximity-labeling technique BioID identifies sorting nexin 6 as a member of the insulin-like growth factor 1 (IGF1)-IGF1 receptor pathway.2
255359842014Sorting nexin 6 enhances lamin a synthesis and incorporation into the nuclear envelope.1
306409022019Rab32 interacts with SNX6 and affects retromer-dependent Golgi trafficking.1

Citation

Dessen P

SNX6 (sorting nexin 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42349/snx6-(sorting-nexin-6)