SOD2 (superoxide dismutase 2)

2003-08-01  

Identity

HGNC
SOD2
LOCATION
6q25.3
LOCUSID
6648
ALIAS
GClnc1,IPO-B,IPOB,MNSOD,MVCD6,Mn-SOD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6648
MIM: 147460
HGNC: 11180
Ensembl: ENSG00000285441

Variants:

dbSNP: 6648
ClinVar: 6648
TCGA: ENSG00000285441
COSMIC: SOD2

RNA/Proteins

Pathways

PathwaySourceExternal ID
Huntington's diseaseKEGGko05016
Huntington's diseaseKEGGhsa05016
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
FoxO signaling pathwayKEGGhsa04068
DiseaseREACTOMER-HSA-1643685
Cellular responses to stressREACTOMER-HSA-2262752
Detoxification of Reactive Oxygen SpeciesREACTOMER-HSA-3299685
Longevity regulating pathwayKEGGhsa04211
Longevity regulating pathway - multiple speciesKEGGko04213
Longevity regulating pathway - multiple speciesKEGGhsa04213
Neurodegenerative DiseasesREACTOMER-HSA-8863678
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsREACTOMER-HSA-8862803

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD25495407
PA444065EpilepsyDiseaseClinicalAnnotationassociatedPD
PA444460Heroin DependenceDiseaseClinicalAnnotationassociatedPD29459008
PA446155Precursor Cell Lymphoblastic Leukemia-LymphomaDiseaseClinicalAnnotationassociatedPD27019981
PA448492asparaginaseChemicalClinicalAnnotationassociatedPD27019981
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD
PA450428methotrexateChemicalClinicalAnnotation, MultilinkAnnotationassociatedPD25330300
PA450761paclitaxelChemicalClinicalAnnotationassociatedPD25495407
PA451846valproic acidChemicalClinicalAnnotationassociatedPD
PA452619heroinChemicalClinicalAnnotationassociatedPD29459008

References

Pubmed IDYearTitleCitations
362291952024SOD2 confers anlotinib resistance via regulation of mitochondrial damage in OSCC.2
379217542024Superoxide dismutase 2 scavenges ROS to promote osteogenic differentiation of human periodontal ligament stem cells by regulating Smad3 in alveolar bone-defective rats.2
380397402024The impact of the association between Val16Ala-SOD2 SNP and SOD2 immunohistochemistry expression in the prognosis of patients with esophageal cancer.0
381545712024Overexpression of manganese superoxide dismutase mitigates ACL injury-induced muscle atrophy, weakness and oxidative damage.1
383103542024SOD2 promotes the immunosuppressive function of mesenchymal stem cells at the expense of adipocyte differentiation.0
383757212024Variants rs2758346, rs5746094, and rs2758331 of SOD2 gene: association study with breast cancer in a Mexican population and their analysis in silico.0
384042152024Methyltransferase METTL3-mediated maturation of miR-4654 facilitates high glucose-induced apoptosis and oxidative stress in lens epithelial cells via decreasing SOD2.1
384128032024SOD2 orchestrates redox homeostasis in intervertebral discs: A novel insight into oxidative stress-mediated degeneration and therapeutic potential.3
362291952024SOD2 confers anlotinib resistance via regulation of mitochondrial damage in OSCC.2
379217542024Superoxide dismutase 2 scavenges ROS to promote osteogenic differentiation of human periodontal ligament stem cells by regulating Smad3 in alveolar bone-defective rats.2
380397402024The impact of the association between Val16Ala-SOD2 SNP and SOD2 immunohistochemistry expression in the prognosis of patients with esophageal cancer.0
381545712024Overexpression of manganese superoxide dismutase mitigates ACL injury-induced muscle atrophy, weakness and oxidative damage.1
383103542024SOD2 promotes the immunosuppressive function of mesenchymal stem cells at the expense of adipocyte differentiation.0
383757212024Variants rs2758346, rs5746094, and rs2758331 of SOD2 gene: association study with breast cancer in a Mexican population and their analysis in silico.0
384042152024Methyltransferase METTL3-mediated maturation of miR-4654 facilitates high glucose-induced apoptosis and oxidative stress in lens epithelial cells via decreasing SOD2.1

Citation

Dessen P

SOD2 (superoxide dismutase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42353/sod2-(superoxide-dismutase-2)