Identity
HGNC
LOCATION
2p22.1
LOCUSID
ALIAS
GF1,GGF1,GINGF,HGF,NS4,SOS-1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6654
MIM: 182530
HGNC: 11187
Ensembl: ENSG00000115904
Variants:
dbSNP: 6654
ClinVar: 6654
TCGA: ENSG00000115904
COSMIC: SOS1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000115904 | ENST00000395038 | G5E9C8 |
| ENSG00000115904 | ENST00000402219 | Q07889 |
| ENSG00000115904 | ENST00000451331 | C9K0N6 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA30592 | MAP3K1 | Gene | Pathway | associated | |||
| PA34183 | RAF1 | Gene | Pathway | associated | |||
| PA7360 | EGFR | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38622665 | 2024 | DNMT1/miR-152-3p/SOS1 signaling axis promotes self-renewal and tumor growth of cancer stem-like cells derived from non-small cell lung cancer. | 0 |
| 38622665 | 2024 | DNMT1/miR-152-3p/SOS1 signaling axis promotes self-renewal and tumor growth of cancer stem-like cells derived from non-small cell lung cancer. | 0 |
| 35475426 | 2023 | Cardiac features of Noonan syndrome in Japanese patients. | 2 |
| 37042566 | 2023 | Translational relevance of SOS1 targeting for KRAS-mutant colorectal cancer. | 2 |
| 37972068 | 2023 | SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status. | 2 |
| 35475426 | 2023 | Cardiac features of Noonan syndrome in Japanese patients. | 2 |
| 37042566 | 2023 | Translational relevance of SOS1 targeting for KRAS-mutant colorectal cancer. | 2 |
| 37972068 | 2023 | SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status. | 2 |
| 35041140 | 2022 | Knockdown of circRNA-Memo1 Reduces Hypoxia/Reoxygenation Injury in Human Brain Endothelial Cells Through miRNA-17-5p/SOS1 Axis. | 14 |
| 35152853 | 2022 | miR-148b-3p, as a tumor suppressor, targets son of sevenless homolog 1 to regulate the malignant progression in human osteosarcoma. | 3 |
| 36403479 | 2022 | SOS1 regulates HCC cell epithelial-mesenchymal transition via the PI3K/AKT/mTOR pathway. | 3 |
| 36446400 | 2022 | Lack of embryonic homozygous or adult heterozygous lymphatic phenotypes for a Sos1 mutation and lack of lymphatic embryonic phenotypes for a homozygous Cx47 mutation in mice. | 0 |
| 35041140 | 2022 | Knockdown of circRNA-Memo1 Reduces Hypoxia/Reoxygenation Injury in Human Brain Endothelial Cells Through miRNA-17-5p/SOS1 Axis. | 14 |
| 35152853 | 2022 | miR-148b-3p, as a tumor suppressor, targets son of sevenless homolog 1 to regulate the malignant progression in human osteosarcoma. | 3 |
| 36403479 | 2022 | SOS1 regulates HCC cell epithelial-mesenchymal transition via the PI3K/AKT/mTOR pathway. | 3 |
Citation
Dessen P
SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/42355/sos1-(sos-ras-rac-guanine-nucleotide-exchange-factor-1)
