Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6655
MIM: 601247
HGNC: 11188
Ensembl: ENSG00000100485
Variants:
dbSNP: 6655
ClinVar: 6655
TCGA: ENSG00000100485
COSMIC: SOS2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000100485 | ENST00000216373 | Q07890 |
| ENSG00000100485 | ENST00000543680 | Q07890 |
| ENSG00000100485 | ENST00000555794 | A0A087X277 |
| ENSG00000100485 | ENST00000556452 | G3V5W3 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37029817 | 2023 | Genetic variants of SOS2, MAP2K1 and RASGRF2 in the RAS pathway genes predict survival of HBV-related hepatocellular carcinoma patients. | 4 |
| 37029817 | 2023 | Genetic variants of SOS2, MAP2K1 and RASGRF2 in the RAS pathway genes predict survival of HBV-related hepatocellular carcinoma patients. | 4 |
| 32788663 | 2021 | Variants of SOS2 are a rare cause of Noonan syndrome with particular predisposition for lymphatic complications. | 9 |
| 33750022 | 2021 | First prenatal case of Noonan syndrome with SOS2 mutation: Implications of early diagnosis for genetic counseling. | 1 |
| 32788663 | 2021 | Variants of SOS2 are a rare cause of Noonan syndrome with particular predisposition for lymphatic complications. | 9 |
| 33750022 | 2021 | First prenatal case of Noonan syndrome with SOS2 mutation: Implications of early diagnosis for genetic counseling. | 1 |
| 30536836 | 2019 | microRNA-148a-3p inhibited the proliferation and epithelial-mesenchymal transition progression of non-small-cell lung cancer via modulating Ras/MAPK/Erk signaling. | 33 |
| 30536836 | 2019 | microRNA-148a-3p inhibited the proliferation and epithelial-mesenchymal transition progression of non-small-cell lung cancer via modulating Ras/MAPK/Erk signaling. | 33 |
| 25795793 | 2015 | Rare variants in SOS2 and LZTR1 are associated with Noonan syndrome. | 89 |
| 26173643 | 2015 | Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome. | 36 |
| 25795793 | 2015 | Rare variants in SOS2 and LZTR1 are associated with Noonan syndrome. | 89 |
| 26173643 | 2015 | Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome. | 36 |
| 23761422 | 2013 | A pharmacogenomic approach to the treatment of children with GH deficiency or Turner syndrome. | 15 |
| 23761422 | 2013 | A pharmacogenomic approach to the treatment of children with GH deficiency or Turner syndrome. | 15 |
| 19911011 | 2010 | Mutation of ARHGAP9 in patients with coronary spastic angina. | 0 |
Citation
Dessen P
SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/42356/sos2-(sos-ras-rho-guanine-nucleotide-exchange-factor-2)
