Identity
HGNC
LOCATION
6p21.31
LOCUSID
ALIAS
PDEF,bA375E1.3
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 25803
MIM: 608144
HGNC: 17257
Ensembl: ENSG00000124664
Variants:
dbSNP: 25803
ClinVar: 25803
TCGA: ENSG00000124664
COSMIC: SPDEF
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000124664 | ENST00000374037 | O95238 |
| ENSG00000124664 | ENST00000544425 | O95238 |
Expression (GTEx)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37515878 | 2023 | Lactobacillus rhamnosus 76 alleviates airway inflammation in ovalbumin-allergic mice and improves mucus secretion by down-regulating STAT6/SPDEF pathway. | 2 |
| 37633945 | 2023 | SPDEF enhances cancer stem cell-like properties and tumorigenesis through directly promoting GALNT7 transcription in luminal breast cancer. | 1 |
| 37900138 | 2023 | Regulation of SPDEF expression by DNA methylation in advanced prostate cancer. | 0 |
| 37515878 | 2023 | Lactobacillus rhamnosus 76 alleviates airway inflammation in ovalbumin-allergic mice and improves mucus secretion by down-regulating STAT6/SPDEF pathway. | 2 |
| 37633945 | 2023 | SPDEF enhances cancer stem cell-like properties and tumorigenesis through directly promoting GALNT7 transcription in luminal breast cancer. | 1 |
| 37900138 | 2023 | Regulation of SPDEF expression by DNA methylation in advanced prostate cancer. | 0 |
| 35951453 | 2022 | The role of SPDEF in cancer: promoter or suppressor. | 3 |
| 35951453 | 2022 | The role of SPDEF in cancer: promoter or suppressor. | 3 |
| 34191390 | 2021 | The subtype-specific molecular function of SPDEF in breast cancer and insights into prognostic significance. | 5 |
| 34667150 | 2021 | SPDEF suppresses head and neck squamous cell carcinoma progression by transcriptionally activating NR4A1. | 11 |
| 34191390 | 2021 | The subtype-specific molecular function of SPDEF in breast cancer and insights into prognostic significance. | 5 |
| 34667150 | 2021 | SPDEF suppresses head and neck squamous cell carcinoma progression by transcriptionally activating NR4A1. | 11 |
| 31596609 | 2020 | Efficient RNP-directed Human Gene Targeting Reveals SPDEF Is Required for IL-13-induced Mucostasis. | 22 |
| 33232357 | 2020 | Assessment of mucin-related gene alterations following treatment with rebamipide ophthalmic suspension in Sjögren's syndrome-associated dry eyes. | 4 |
| 31596609 | 2020 | Efficient RNP-directed Human Gene Targeting Reveals SPDEF Is Required for IL-13-induced Mucostasis. | 22 |
Citation
Dessen P
SPDEF (SAM pointed domain containing ETS transcription factor)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/42372/spdef-(sam-pointed-domain-containing-ets-transcription-factor)
