SPON2 (spondin 2)

2003-02-01  

Identity

HGNC
SPON2
LOCATION
4p16.3
LOCUSID
10417
ALIAS
DIL-1,DIL1,M-SPONDIN,MINDIN

Other Information

Locus ID:

NCBI: 10417
MIM: 605918
HGNC: 11253
Ensembl: ENSG00000159674

Variants:

dbSNP: 10417
ClinVar: 10417
TCGA: ENSG00000159674
COSMIC: SPON2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159674ENST00000290902Q9BUD6
ENSG00000159674ENST00000431380Q9BUD6
ENSG00000159674ENST00000502483D6RBY3
ENSG00000159674ENST00000503765D6RB12
ENSG00000159674ENST00000509233D6RFY9
ENSG00000159674ENST00000511672A0A1Y8ELY7
ENSG00000159674ENST00000511679D6RA41
ENSG00000159674ENST00000514490D6REX2
ENSG00000159674ENST00000515004D6RIH5
ENSG00000159674ENST00000617421Q9BUD6

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-glycosylation of TSR domain-containing proteinsREACTOMER-HSA-5173214
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Diseases associated with O-glycosylation of proteinsREACTOMER-HSA-3906995
Defective B3GALTL causes Peters-plus syndrome (PpS)REACTOMER-HSA-5083635

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
364277762023SPON2 promotes the bone metastasis of lung adenocarcinoma via activation of the NF-κB signaling pathway.6
364844102023Prostate cancer cell‑derived spondin 2 boosts osteogenic factor levels in osteoblasts via the PI3K/AKT/mTOR pathway.1
371301062023In situ assessment of Mindin as a biomarker of podocyte lesions in diabetic nephropathy.0
377138322023Comprehensive analysis of the oncogenic and immunological role of SPON2 in human tumors.1
364277762023SPON2 promotes the bone metastasis of lung adenocarcinoma via activation of the NF-κB signaling pathway.6
364844102023Prostate cancer cell‑derived spondin 2 boosts osteogenic factor levels in osteoblasts via the PI3K/AKT/mTOR pathway.1
371301062023In situ assessment of Mindin as a biomarker of podocyte lesions in diabetic nephropathy.0
377138322023Comprehensive analysis of the oncogenic and immunological role of SPON2 in human tumors.1
339980762021The clinical significance of spondin 2 eccentric expression in peripheral blood mononuclear cells in bronchial asthma.8
341833852021Cancer-associated Fibroblast-derived Spondin-2 Promotes Motility of Gastric Cancer Cells.11
345837502021Tumor cell-derived SPON2 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by activating PYK2 in CRC.35
339980762021The clinical significance of spondin 2 eccentric expression in peripheral blood mononuclear cells in bronchial asthma.8
341833852021Cancer-associated Fibroblast-derived Spondin-2 Promotes Motility of Gastric Cancer Cells.11
345837502021Tumor cell-derived SPON2 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by activating PYK2 in CRC.35
316914942020Spondin 2 promotes the proliferation, migration and invasion of gastric cancer cells.26

Citation

Dessen P

SPON2 (spondin 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42378/spon2-(spondin-2)