Identity
HGNC
LOCATION
22q13.2
LOCUSID
ALIAS
SREBP-2,SREBP2,bHLHd2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6721
MIM: 600481
HGNC: 11290
Ensembl: ENSG00000198911
Variants:
dbSNP: 6721
ClinVar: 6721
TCGA: ENSG00000198911
COSMIC: SREBF2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37378670 | 2024 | A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes. | 5 |
| 38581859 | 2024 | ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2. | 0 |
| 38728412 | 2024 | A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression. | 0 |
| 37378670 | 2024 | A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes. | 5 |
| 38581859 | 2024 | ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2. | 0 |
| 38728412 | 2024 | A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression. | 0 |
| 35642354 | 2023 | SREBF2-STARD4 axis confers sorafenib resistance in hepatocellular carcinoma by regulating mitochondrial cholesterol homeostasis. | 12 |
| 36519761 | 2023 | Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway-implications for Parkinson's disease. | 3 |
| 36934350 | 2023 | Sterol regulatory element-binding protein 2 maintains glioblastoma stem cells by keeping the balance between cholesterol biosynthesis and uptake. | 3 |
| 37042569 | 2023 | LATS-regulated nuclear-cytoplasmic translocation of SREBP2 inhibits hepatocellular carcinoma cell migration and invasion via epithelial-mesenchymal transition. | 2 |
| 37647408 | 2023 | Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells. | 0 |
| 38092754 | 2023 | Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis. | 0 |
| 35642354 | 2023 | SREBF2-STARD4 axis confers sorafenib resistance in hepatocellular carcinoma by regulating mitochondrial cholesterol homeostasis. | 12 |
| 36519761 | 2023 | Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway-implications for Parkinson's disease. | 3 |
| 36934350 | 2023 | Sterol regulatory element-binding protein 2 maintains glioblastoma stem cells by keeping the balance between cholesterol biosynthesis and uptake. | 3 |
Citation
Dessen P
SREBF2 (sterol regulatory element binding transcription factor 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/42387/srebf2-(sterol-regulatory-element-binding-transcription-factor-2)
