SSR2 (signal sequence receptor subunit 2)

2003-06-01

Identity

HGNC

SSR2

LOCATION

1q22

LOCUSID

6746

ALIAS

HSD25,TLAP,TRAP-BETA,TRAPB

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6746
MIM: 600867
HGNC: 11324
Ensembl: ENSG00000163479

Variants:

dbSNP: 6746
ClinVar: 6746
TCGA: ENSG00000163479
COSMIC: SSR2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000163479	ENST00000295702	P43308
ENSG00000163479	ENST00000466905	E9PJ35
ENSG00000163479	ENST00000473699	E9PNP2
ENSG00000163479	ENST00000474377	E9PJ35
ENSG00000163479	ENST00000480567	P43308
ENSG00000163479	ENST00000496742	E9PQJ7
ENSG00000163479	ENST00000526212	E9PQ05
ENSG00000163479	ENST00000529008	E9PN13
ENSG00000163479	ENST00000531790	E9PLP2
ENSG00000163479	ENST00000531917	E9PQI4

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Expression (GTEx)

100

150

200

250

300

350

400

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
Metabolism of proteins	REACTOME	R-HSA-392499
Protein processing in endoplasmic reticulum	KEGG	ko04141
Protein processing in endoplasmic reticulum	KEGG	hsa04141
SRP-dependent cotranslational protein targeting to membrane	REACTOME	R-HSA-1799339
Translation	REACTOME	R-HSA-72766
Translocon-associated protein (TRAP) complex	KEGG	hsa_M00402
Translocon-associated protein (TRAP) complex	KEGG	M00402

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References

Pubmed ID	Year	Title	Citations
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
27180333	2016	Signal Sequence Receptor 2 is required for survival of human melanoma cells as part of an unfolded protein response to endoplasmic reticulum stress.	8
27180333	2016	Signal Sequence Receptor 2 is required for survival of human melanoma cells as part of an unfolded protein response to endoplasmic reticulum stress.	8
33137310	2020	Translocon-Associated Protein Complex (TRAP) is Crucial for Co-Translational Translocation of Pre-Proinsulin.	14
33137310	2020	Translocon-Associated Protein Complex (TRAP) is Crucial for Co-Translational Translocation of Pre-Proinsulin.	14

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Citation

Dessen P

SSR2 (signal sequence receptor subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42398/ssr2-(signal-sequence-receptor-subunit-2)