SSR3 (signal sequence receptor subunit 3)

2003-06-01  

Identity

HGNC
LOCATION
3q25.31
LOCUSID
ALIAS
TRAPG
FUSION GENES

Other Information

Locus ID:

NCBI: 6747
MIM: 606213
HGNC: 11325
Ensembl: ENSG00000114850

Variants:

dbSNP: 6747
ClinVar: 6747
TCGA: ENSG00000114850
COSMIC: SSR3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114850ENST00000265044Q9UNL2
ENSG00000114850ENST00000463503C9J365
ENSG00000114850ENST00000467789Q9UNL2
ENSG00000114850ENST00000476217C9JA28
ENSG00000114850ENST00000496050C9J365

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Translocon-associated protein (TRAP) complexKEGGhsa_M00402
Translocon-associated protein (TRAP) complexKEGGM00402
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Gene ExpressionREACTOMER-HSA-74160

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
376523952023Signal sequence receptor subunit 3: A novel indicator of immunosuppressive tumor microenvironment and clinical benefits from immunotherapy.0
376523952023Signal sequence receptor subunit 3: A novel indicator of immunosuppressive tumor microenvironment and clinical benefits from immunotherapy.0
348575432022The Role of TRAPγ/SSR3 in Preproinsulin Translocation Into the Endoplasmic Reticulum.2
355526772022Translocon-associated Protein Subunit SSR3 Determines and Predicts Susceptibility to Paclitaxel in Breast Cancer and Glioblastoma.4
348575432022The Role of TRAPγ/SSR3 in Preproinsulin Translocation Into the Endoplasmic Reticulum.2
355526772022Translocon-associated Protein Subunit SSR3 Determines and Predicts Susceptibility to Paclitaxel in Breast Cancer and Glioblastoma.4
323321022021TRAPγ-CDG shows asymmetric glycosylation and an effect on processing of proteins required in higher organisms.6
323321022021TRAPγ-CDG shows asymmetric glycosylation and an effect on processing of proteins required in higher organisms.6
309453122019Mutations in the translocon-associated protein complex subunit SSR3 cause a novel congenital disorder of glycosylation.10
309453122019Mutations in the translocon-associated protein complex subunit SSR3 cause a novel congenital disorder of glycosylation.10
299402862018Overexpression of signal sequence receptor γ predicts poor survival in patients with hepatocellular carcinoma.12
299402862018Overexpression of signal sequence receptor γ predicts poor survival in patients with hepatocellular carcinoma.12
282182522017Dissecting the molecular organization of the translocon-associated protein complex.64
282182522017Dissecting the molecular organization of the translocon-associated protein complex.64
236602952013The orphan nuclear receptor TR3/Nur77 regulates ER stress and induces apoptosis via interaction with TRAPγ.9

Citation

Dessen P

SSR3 (signal sequence receptor subunit 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42399/ssr3-(signal-sequence-receptor-subunit-3)